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Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis.

Naruo T, Nakabeppu Y, Deguchi D, Nagai N, Tsutsui J, Nakajo M, Nozoe S - BMC Psychiatry (2001)

Bottom Line: All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed.After statistical analysis of each brain image, the relationships among images were evaluated.These findings suggest that some localized functions of the ACCare possibly relevant to the psychopathological aspects of AN-R.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychosomatic Medicine, Kagoshima University Hospital, 8-35-1, Sakuragaoka, Kagoshima-City, Japan. naruo@m.kufm.kagoshima-u.ac.jp

ABSTRACT

Background: It is possible that psychopathological differences exist between the restricting and bulimic forms of anorexia nervosa. We investigated localized differences of brain blood flow of anorexia nervosa patients using SPECT image analysis with statistic parametric mapping (SPM) in an attempt to link brain blood flow patterns to neurophysiologic characteristics.

Methods: The subjects enrolled in this study included the following three groups: pure restrictor anorexics (AN-R), anorexic bulimics (AN-BP), and healthy volunteers (HV). All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed. After statistical analysis of each brain image, the relationships among images were evaluated.

Results: SPM analysis of the SPECT images revealed that the blood flow of frontal area mainly containing bilateral anterior cingulate gyri (ACC) was significantly decreased in the AN-R group compared to the AN-BP and HV groups.

Conclusions: These findings suggest that some localized functions of the ACCare possibly relevant to the psychopathological aspects of AN-R.

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Related in: MedlinePlus

The statistical parametric mapping (SPM) of areas of decreased rCBF in the anorexia nervosa restricter group. Decreased of rCBF are also shown in the bilateral anterior parts of cingulate gyri (ACC: Brodmann's areas 24) and parts of frontal regions (parts of areas 8, 9,10 and 32) when compared to the anorexia nervosa patients with binge/purge eating (p < 0.001, extent = 550)
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Figure 2: The statistical parametric mapping (SPM) of areas of decreased rCBF in the anorexia nervosa restricter group. Decreased of rCBF are also shown in the bilateral anterior parts of cingulate gyri (ACC: Brodmann's areas 24) and parts of frontal regions (parts of areas 8, 9,10 and 32) when compared to the anorexia nervosa patients with binge/purge eating (p < 0.001, extent = 550)

Mentions: SPM analysis of SPECT images revealed that the blood flow of the bilateral anterior parts of cingulate gyri (ACC: Brodmann's areas 24) and parts of frontal regions (parts of areas 8, 9,10 and 32) were significantly decreased in the AN-R group in comparison with that in the HV (p < 0.05) (Figure 1). In comparison with the AN-BP group, SPM analysis showed significantly decreased areas within almostthe same bilateral anterior parts of the frontal lobes (Figure 2). On the other hand, comparing with the HV or AN-R group, SPM analysis found no significant change of rCBF in the AN-BP group.


Decreases in blood perfusion of the anterior cingulate gyri in Anorexia Nervosa Restricters assessed by SPECT image analysis.

Naruo T, Nakabeppu Y, Deguchi D, Nagai N, Tsutsui J, Nakajo M, Nozoe S - BMC Psychiatry (2001)

The statistical parametric mapping (SPM) of areas of decreased rCBF in the anorexia nervosa restricter group. Decreased of rCBF are also shown in the bilateral anterior parts of cingulate gyri (ACC: Brodmann's areas 24) and parts of frontal regions (parts of areas 8, 9,10 and 32) when compared to the anorexia nervosa patients with binge/purge eating (p < 0.001, extent = 550)
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC32312&req=5

Figure 2: The statistical parametric mapping (SPM) of areas of decreased rCBF in the anorexia nervosa restricter group. Decreased of rCBF are also shown in the bilateral anterior parts of cingulate gyri (ACC: Brodmann's areas 24) and parts of frontal regions (parts of areas 8, 9,10 and 32) when compared to the anorexia nervosa patients with binge/purge eating (p < 0.001, extent = 550)
Mentions: SPM analysis of SPECT images revealed that the blood flow of the bilateral anterior parts of cingulate gyri (ACC: Brodmann's areas 24) and parts of frontal regions (parts of areas 8, 9,10 and 32) were significantly decreased in the AN-R group in comparison with that in the HV (p < 0.05) (Figure 1). In comparison with the AN-BP group, SPM analysis showed significantly decreased areas within almostthe same bilateral anterior parts of the frontal lobes (Figure 2). On the other hand, comparing with the HV or AN-R group, SPM analysis found no significant change of rCBF in the AN-BP group.

Bottom Line: All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed.After statistical analysis of each brain image, the relationships among images were evaluated.These findings suggest that some localized functions of the ACCare possibly relevant to the psychopathological aspects of AN-R.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychosomatic Medicine, Kagoshima University Hospital, 8-35-1, Sakuragaoka, Kagoshima-City, Japan. naruo@m.kufm.kagoshima-u.ac.jp

ABSTRACT

Background: It is possible that psychopathological differences exist between the restricting and bulimic forms of anorexia nervosa. We investigated localized differences of brain blood flow of anorexia nervosa patients using SPECT image analysis with statistic parametric mapping (SPM) in an attempt to link brain blood flow patterns to neurophysiologic characteristics.

Methods: The subjects enrolled in this study included the following three groups: pure restrictor anorexics (AN-R), anorexic bulimics (AN-BP), and healthy volunteers (HV). All images were transformed into the standard anatomical space of the stereotactic brain atlas, then smoothed. After statistical analysis of each brain image, the relationships among images were evaluated.

Results: SPM analysis of the SPECT images revealed that the blood flow of frontal area mainly containing bilateral anterior cingulate gyri (ACC) was significantly decreased in the AN-R group compared to the AN-BP and HV groups.

Conclusions: These findings suggest that some localized functions of the ACCare possibly relevant to the psychopathological aspects of AN-R.

Show MeSH
Related in: MedlinePlus