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Trapping Iron Oxide into Hollow Gold Nanoparticles

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ABSTRACT

Synthesis of the core/shell-structured Fe3O4/Au nanoparticles by trapping Fe3O4 inside hollow Au nanoparticles is described. The produced composite nanoparticles are strongly magnetic with their surface plasmon resonance peaks in the near infrared region (wavelength from 700 to 800 nm), combining desirable magnetic and plasmonic properties into one nanoparticle. They are particularly suitable for in vivo diagnostic and therapeutic applications. The intact Au surface provides convenient anchorage sites for attachment of targeting molecules, and the particles can be activated by both near infrared lights and magnetic fields. As more and more hollow nanoparticles become available, this synthetic method would find general applications in the fabrication of core–shell multifunctional nanostructures.

No MeSH data available.


TEM micrographs of PHAuNPs before a and after b loading iron oxide nanoparticles.
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Figure 2: TEM micrographs of PHAuNPs before a and after b loading iron oxide nanoparticles.

Mentions: Figure 2 shows TEM analysis before and after loading of iron oxide nanoparticles. After loading, the hollow core of PHAuNPs is occupied by solid substances. During the precipitation, Fe3O4 nanoparticles also formed outside of PHAuNPs, but TEM micrographs clearly show that no small iron oxide nanoparticles were attached to the PHAuNP surface. This is in agreement with the common notion that iron oxide usually does not stick to the Au surface [11]. Given the very different sizes of PHAuNPs (~100 nm) and non-trapped Fe3O4 nanoparticles (<20 nm), they can be readily separated using centrifugation.


Trapping Iron Oxide into Hollow Gold Nanoparticles
TEM micrographs of PHAuNPs before a and after b loading iron oxide nanoparticles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211847&req=5

Figure 2: TEM micrographs of PHAuNPs before a and after b loading iron oxide nanoparticles.
Mentions: Figure 2 shows TEM analysis before and after loading of iron oxide nanoparticles. After loading, the hollow core of PHAuNPs is occupied by solid substances. During the precipitation, Fe3O4 nanoparticles also formed outside of PHAuNPs, but TEM micrographs clearly show that no small iron oxide nanoparticles were attached to the PHAuNP surface. This is in agreement with the common notion that iron oxide usually does not stick to the Au surface [11]. Given the very different sizes of PHAuNPs (~100 nm) and non-trapped Fe3O4 nanoparticles (<20 nm), they can be readily separated using centrifugation.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

Synthesis of the core/shell-structured Fe3O4/Au nanoparticles by trapping Fe3O4 inside hollow Au nanoparticles is described. The produced composite nanoparticles are strongly magnetic with their surface plasmon resonance peaks in the near infrared region (wavelength from 700 to 800 nm), combining desirable magnetic and plasmonic properties into one nanoparticle. They are particularly suitable for in vivo diagnostic and therapeutic applications. The intact Au surface provides convenient anchorage sites for attachment of targeting molecules, and the particles can be activated by both near infrared lights and magnetic fields. As more and more hollow nanoparticles become available, this synthetic method would find general applications in the fabrication of core&ndash;shell multifunctional nanostructures.

No MeSH data available.