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Synthesis and characterisation of biologically compatible TiO2 nanoparticles.

Cheyne RW, Smith TA, Trembleau L, McLaughlin AC - Nanoscale Res Lett (2011)

Bottom Line: We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water.The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported.We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Chemistry Department, University of Aberdeen, AB24 3 UE, UK. a.c.mclaughlin@abdn.ac.uk.

ABSTRACT
We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation, these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance.

No MeSH data available.


TEM images of (a) SA-coated and (b) Asp-coated TiO2 nanoparticles.
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Figure 1: TEM images of (a) SA-coated and (b) Asp-coated TiO2 nanoparticles.

Mentions: The TEM images of SA- and Asp-coated TiO2 nanoparticles are presented in Figure 1. The TEM images for the other coated nanoparticles and higher magnification images are displayed in the Additional file (Figures S1 and S2 in Additional file 1). The higher magnification shows that the nanoparticles prepared are spherical with a uniform diameter of 5 ± 1 nm, but that the nanoparticles agglomerate. Such agglomeration/aggregation of TiO2 nanoparticles is well documented and can be tuned by altering the pH (for example see references [9,18,19]). The mean hydrodynamic radius was determined using dynamic light scattering, and the results are displayed in Table 2 and confirm that when dispersed in solution, the coated TiO2 nanoparticles form agglomerates which vary in size from 141 to 601 nm. Powder X-ray diffraction (XRD) patterns of SA- and Asp-coated nanoparticles are shown in Figure 2. The diffraction patterns show that the anatase phase (JCPDS no. 21-1272) is formed, and the crystallite size was calculated at 5 nm using the Scherrer formula which is in good agreement with the TEM images [20]. The XRD patterns of the Benz, Boc-Gly, Boc-Asp, Mercapto and Gly surface-modified TiO2 nanoparticles are displayed in Figures S3 and S4 in Additional file 1. There is no change in particle size or crystal structure upon surface modification.


Synthesis and characterisation of biologically compatible TiO2 nanoparticles.

Cheyne RW, Smith TA, Trembleau L, McLaughlin AC - Nanoscale Res Lett (2011)

TEM images of (a) SA-coated and (b) Asp-coated TiO2 nanoparticles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211840&req=5

Figure 1: TEM images of (a) SA-coated and (b) Asp-coated TiO2 nanoparticles.
Mentions: The TEM images of SA- and Asp-coated TiO2 nanoparticles are presented in Figure 1. The TEM images for the other coated nanoparticles and higher magnification images are displayed in the Additional file (Figures S1 and S2 in Additional file 1). The higher magnification shows that the nanoparticles prepared are spherical with a uniform diameter of 5 ± 1 nm, but that the nanoparticles agglomerate. Such agglomeration/aggregation of TiO2 nanoparticles is well documented and can be tuned by altering the pH (for example see references [9,18,19]). The mean hydrodynamic radius was determined using dynamic light scattering, and the results are displayed in Table 2 and confirm that when dispersed in solution, the coated TiO2 nanoparticles form agglomerates which vary in size from 141 to 601 nm. Powder X-ray diffraction (XRD) patterns of SA- and Asp-coated nanoparticles are shown in Figure 2. The diffraction patterns show that the anatase phase (JCPDS no. 21-1272) is formed, and the crystallite size was calculated at 5 nm using the Scherrer formula which is in good agreement with the TEM images [20]. The XRD patterns of the Benz, Boc-Gly, Boc-Asp, Mercapto and Gly surface-modified TiO2 nanoparticles are displayed in Figures S3 and S4 in Additional file 1. There is no change in particle size or crystal structure upon surface modification.

Bottom Line: We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water.The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported.We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology.

View Article: PubMed Central - HTML - PubMed

Affiliation: The Chemistry Department, University of Aberdeen, AB24 3 UE, UK. a.c.mclaughlin@abdn.ac.uk.

ABSTRACT
We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation, these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance.

No MeSH data available.