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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


Drug release patterns of CP-MMT systems at pH = 1.2.
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Figure 8: Drug release patterns of CP-MMT systems at pH = 1.2.

Mentions: The controlled release patterns and pH dependences of the rate of CP release from each of the CP-MMT matrixes are illustrated by the cumulative drug release data presented in Figures 8 and 9. In intestinal-fluid-mimicking medium (pH 7.4), CP release over 9 h was 22, 21 and 4%, respectively, for CP-MMT prepared by the melt, solution and grinding methods, Table 2. Corresponding values for the gastric-fluid-mimicking medium (pH 1.2) were considerably lower, indicating the potential of the formulation to exhibit small-intestine selectivity.


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
Drug release patterns of CP-MMT systems at pH = 1.2.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 8: Drug release patterns of CP-MMT systems at pH = 1.2.
Mentions: The controlled release patterns and pH dependences of the rate of CP release from each of the CP-MMT matrixes are illustrated by the cumulative drug release data presented in Figures 8 and 9. In intestinal-fluid-mimicking medium (pH 7.4), CP release over 9 h was 22, 21 and 4%, respectively, for CP-MMT prepared by the melt, solution and grinding methods, Table 2. Corresponding values for the gastric-fluid-mimicking medium (pH 1.2) were considerably lower, indicating the potential of the formulation to exhibit small-intestine selectivity.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.