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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


Thermograms of CP-MMT systems.
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Figure 7: Thermograms of CP-MMT systems.

Mentions: The thermogram of MMT is characterized by a 7% mass loss, which at the heating rate of 10°C/min occurred over the temperature range of 48–120°C and is consistent with the desorption of water molecules from MMT. The thermograms of CP-MMT systems are characterized by the decomposition of intercalated CP (200–250°C) and by a second mass loss of 6% (430–450°C), which corresponds to the structural dehydroxylation of MMT, Figure 7.


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
Thermograms of CP-MMT systems.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 7: Thermograms of CP-MMT systems.
Mentions: The thermogram of MMT is characterized by a 7% mass loss, which at the heating rate of 10°C/min occurred over the temperature range of 48–120°C and is consistent with the desorption of water molecules from MMT. The thermograms of CP-MMT systems are characterized by the decomposition of intercalated CP (200–250°C) and by a second mass loss of 6% (430–450°C), which corresponds to the structural dehydroxylation of MMT, Figure 7.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.