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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


XRD patterns for MMT and for CP-MMT systems.
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Figure 6: XRD patterns for MMT and for CP-MMT systems.

Mentions: Comparison of the XRD pattern of pure MMT with those of CP-MMT composites from solution, melt or grinding methods (Figure 6) confirms that the clay retains its structure following intercalation. Consistent with previous reports that the method of intercalation impacts upon the d-spacing of the carrier mineral [27,28], the characteristic (001) peak of pure MMT (2[θ] = 9.9°) shifts to 11, 11.5 and 9.6°, respectively, for CP-MMT composites prepared by solution, melt or grinding methods. The interlayer distances CP-MMT systems prepared by solution, melt and grinding methods were characterized by respective basal spacing values of 1.7, 2.4 and 1.6 nm (Table 1). Since the corresponding distance for MMT is 1.3 nm, the more open structure at the (001) plane of CP-MMT composites is interpreted as evidence for the successful intercalation of CP into the interlayer structure of the mineral.


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
XRD patterns for MMT and for CP-MMT systems.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 6: XRD patterns for MMT and for CP-MMT systems.
Mentions: Comparison of the XRD pattern of pure MMT with those of CP-MMT composites from solution, melt or grinding methods (Figure 6) confirms that the clay retains its structure following intercalation. Consistent with previous reports that the method of intercalation impacts upon the d-spacing of the carrier mineral [27,28], the characteristic (001) peak of pure MMT (2[θ] = 9.9°) shifts to 11, 11.5 and 9.6°, respectively, for CP-MMT composites prepared by solution, melt or grinding methods. The interlayer distances CP-MMT systems prepared by solution, melt and grinding methods were characterized by respective basal spacing values of 1.7, 2.4 and 1.6 nm (Table 1). Since the corresponding distance for MMT is 1.3 nm, the more open structure at the (001) plane of CP-MMT composites is interpreted as evidence for the successful intercalation of CP into the interlayer structure of the mineral.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.