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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


Drug-loading capacities of CP-MMT systems prepared by solution, melt and grinding intercalation.
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Figure 4: Drug-loading capacities of CP-MMT systems prepared by solution, melt and grinding intercalation.

Mentions: The drug-loading capacities for CP-MMT systems that had been formed by the solution, melt and grinding methods are presented in Figure 4. In accord with the susceptibility of CP (pKa = 3.7) to hydrolytic degradation, solution intercalation was performed in acidic media. The CP-loading capacity of Na-MMT was very similar to that of MMT-K10.


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
Drug-loading capacities of CP-MMT systems prepared by solution, melt and grinding intercalation.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 4: Drug-loading capacities of CP-MMT systems prepared by solution, melt and grinding intercalation.
Mentions: The drug-loading capacities for CP-MMT systems that had been formed by the solution, melt and grinding methods are presented in Figure 4. In accord with the susceptibility of CP (pKa = 3.7) to hydrolytic degradation, solution intercalation was performed in acidic media. The CP-loading capacity of Na-MMT was very similar to that of MMT-K10.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.