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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


Colloidal dispersions.
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Figure 3: Colloidal dispersions.

Mentions: Accurately weighed amounts of MMT nanoclay (ca. 1, 2 or 5 g) were dispersed separately in vessels containing deionized water (100 ml) and allowed to stand for about 15 h and stirred (magnetic stirrer) for 24 h. The colloidal stability of the dispersions was assessed visually over 24 h. Since all dispersions appeared stable within this timescale, the more concentrated, 5 %w/w MMT, dispersion was selected for further evaluation (Figure 3).


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
Colloidal dispersions.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 3: Colloidal dispersions.
Mentions: Accurately weighed amounts of MMT nanoclay (ca. 1, 2 or 5 g) were dispersed separately in vessels containing deionized water (100 ml) and allowed to stand for about 15 h and stirred (magnetic stirrer) for 24 h. The colloidal stability of the dispersions was assessed visually over 24 h. Since all dispersions appeared stable within this timescale, the more concentrated, 5 %w/w MMT, dispersion was selected for further evaluation (Figure 3).

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.