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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


Zero order, First order, Higuchi and Koresmeyer–Peppas kinetic models at pH 1.2.
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Figure 10: Zero order, First order, Higuchi and Koresmeyer–Peppas kinetic models at pH 1.2.

Mentions: Fitting of the data, from the in vitro release of CP from the CP-MMT matrix, to the theoretical models (Figures 10 and 11) showed that, at both pH values considered, the release profiles of formulations prepared in the melt or by grinding were consistent with near-zero-order kinetics. Comparison of the correlation coefficients (R2, Tables 3 and 4) identified the Higuchi model as that which fits the data best, irrespective of the pH of the release medium. In all the cases, values of n < 0.5 indicated that the drug diffusion mechanism is classical, non-Fickian release, which is assumed to be facilitated by the swelling of the clay matrix [29]. The application of the Korsmeyer–Peppas model was consistent with the suitability of the CP-MMT system to act as an orally administered vehicle for the sustained release of CP [30].


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
Zero order, First order, Higuchi and Koresmeyer–Peppas kinetic models at pH 1.2.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 10: Zero order, First order, Higuchi and Koresmeyer–Peppas kinetic models at pH 1.2.
Mentions: Fitting of the data, from the in vitro release of CP from the CP-MMT matrix, to the theoretical models (Figures 10 and 11) showed that, at both pH values considered, the release profiles of formulations prepared in the melt or by grinding were consistent with near-zero-order kinetics. Comparison of the correlation coefficients (R2, Tables 3 and 4) identified the Higuchi model as that which fits the data best, irrespective of the pH of the release medium. In all the cases, values of n < 0.5 indicated that the drug diffusion mechanism is classical, non-Fickian release, which is assumed to be facilitated by the swelling of the clay matrix [29]. The application of the Korsmeyer–Peppas model was consistent with the suitability of the CP-MMT system to act as an orally administered vehicle for the sustained release of CP [30].

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.