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Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

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ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.


Structure of CP.
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Figure 1: Structure of CP.

Mentions: K10 Montmorillonite nanoclay (specific surface area = 274 m2/g, cation exchange capacity = 119 Meq/100 g) was purchased from Sigma–Aldrich, USA. Captopril (Figure 1; melting point 106°C) was sourced from Medrich pharmaceuticals, India, and was used as received. All the other chemicals used were of analytical grade.


Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics
Structure of CP.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3211200&req=5

Figure 1: Structure of CP.
Mentions: K10 Montmorillonite nanoclay (specific surface area = 274 m2/g, cation exchange capacity = 119 Meq/100 g) was purchased from Sigma–Aldrich, USA. Captopril (Figure 1; melting point 106°C) was sourced from Medrich pharmaceuticals, India, and was used as received. All the other chemicals used were of analytical grade.

View Article: PubMed Central - HTML - PubMed

ABSTRACT

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

No MeSH data available.