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Adventures in public data.

Zaharevitz DW - J Cheminform (2011)

Bottom Line: We, the Editors, wish to make clear however that this is an exception that we made because we would like to preserve the temporal unity and message of this set of publications.Insisting on a formal publication would have meant losing this historical account as part of the thematic series of papers or disrupting the series.We hope that this will find the consent of our readership.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Cancer Institute/NIH, Bethesda, Maryland, USA. zaharevd@mail.nih.gov.

ABSTRACT
This article contains the slides and transcript of a talk given by Dan Zaharevitz at the "Visions of a Semantic Molecular Future" symposium held at the University of Cambridge Department of Chemistry on 2011-01-19. A recording of the talk is available on the University Computing Service's Streaming Media Service archive at http://sms.cam.ac.uk/media/1095515 (unfortunately the first part of the recording was corrupted, so the talk appears to begin at slide 6, 'At a critical time'). We believe that Dan's message comes over extremely well in the textual transcript and that it would be poorer for serious editing. In addition we have added some explanations and references of some of the concepts in the slides and text. (Charlotte Bolton; Peter Murray-Rust, University of Cambridge) EDITORIAL PREFACE: The following paper is part of a series of publications which arose from a Symposium held at the Unilever Centre for Molecular Informatics at the University of Cambridge to celebrate the lifetime achievements of Peter Murray-Rust. One of the motives of Peter's work was and is a better transport and preservation of data and information in scientific publications. In both respects the following publication is relevant: it is about public data and their representation, and the publication represents a non-standard experiment of transporting the content of the scientific presentation. As you will see, it consists of the original slides used by Dan Zaharevitz in his talk "Adventures in Public Data" at the Unilever Centre together with a diligent transcript of his speech. The transcribers have gone through great effort to preserve the original spirit of the talk by preserving colloquial language as it is used at such occasions. For reasons known to us, the original speaker was unable to submit the manuscript in a more conventional form. We, the Editors, have discussed in depth whether such a format is suitable for a scientific journal. We have eventually decided to publish this "as is". We did this mostly because it was Peter's wish that this talk was published in this form and because we agreed with his notion that this format transmits the message just as well as a formal article as defined by our instructions for authors. We, the Editors, wish to make clear however that this is an exception that we made because we would like to preserve the temporal unity and message of this set of publications. Insisting on a formal publication would have meant losing this historical account as part of the thematic series of papers or disrupting the series. We hope that this will find the consent of our readership.

No MeSH data available.


Related in: MedlinePlus

DTP History.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
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Figure 2: DTP History.

Mentions: (Figure 2) The history of the DTP (Developmental Therapeutics Program) starts in 1955 with a US Congress specific appropriation to create a national chemotherapy service centre (Endnote 2). The rationale for this was that at the time there was no interest in attempting to develop anti-cancer drugs within the pharma industry. It was thought not possible to alter the course of the disease. Compounds were screened for anti-cancer activity. The primary screen was transplantable mouse models. Over the course of >50 years that the NCI has been acquiring compounds (Endnote 3), we have registered more than 550,000 compounds. Roughly half of these (280,000) were acquired without confidentiality agreement so that data can be publicly made available.


Adventures in public data.

Zaharevitz DW - J Cheminform (2011)

DTP History.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198951&req=5

Figure 2: DTP History.
Mentions: (Figure 2) The history of the DTP (Developmental Therapeutics Program) starts in 1955 with a US Congress specific appropriation to create a national chemotherapy service centre (Endnote 2). The rationale for this was that at the time there was no interest in attempting to develop anti-cancer drugs within the pharma industry. It was thought not possible to alter the course of the disease. Compounds were screened for anti-cancer activity. The primary screen was transplantable mouse models. Over the course of >50 years that the NCI has been acquiring compounds (Endnote 3), we have registered more than 550,000 compounds. Roughly half of these (280,000) were acquired without confidentiality agreement so that data can be publicly made available.

Bottom Line: We, the Editors, wish to make clear however that this is an exception that we made because we would like to preserve the temporal unity and message of this set of publications.Insisting on a formal publication would have meant losing this historical account as part of the thematic series of papers or disrupting the series.We hope that this will find the consent of our readership.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Cancer Institute/NIH, Bethesda, Maryland, USA. zaharevd@mail.nih.gov.

ABSTRACT
This article contains the slides and transcript of a talk given by Dan Zaharevitz at the "Visions of a Semantic Molecular Future" symposium held at the University of Cambridge Department of Chemistry on 2011-01-19. A recording of the talk is available on the University Computing Service's Streaming Media Service archive at http://sms.cam.ac.uk/media/1095515 (unfortunately the first part of the recording was corrupted, so the talk appears to begin at slide 6, 'At a critical time'). We believe that Dan's message comes over extremely well in the textual transcript and that it would be poorer for serious editing. In addition we have added some explanations and references of some of the concepts in the slides and text. (Charlotte Bolton; Peter Murray-Rust, University of Cambridge) EDITORIAL PREFACE: The following paper is part of a series of publications which arose from a Symposium held at the Unilever Centre for Molecular Informatics at the University of Cambridge to celebrate the lifetime achievements of Peter Murray-Rust. One of the motives of Peter's work was and is a better transport and preservation of data and information in scientific publications. In both respects the following publication is relevant: it is about public data and their representation, and the publication represents a non-standard experiment of transporting the content of the scientific presentation. As you will see, it consists of the original slides used by Dan Zaharevitz in his talk "Adventures in Public Data" at the Unilever Centre together with a diligent transcript of his speech. The transcribers have gone through great effort to preserve the original spirit of the talk by preserving colloquial language as it is used at such occasions. For reasons known to us, the original speaker was unable to submit the manuscript in a more conventional form. We, the Editors, have discussed in depth whether such a format is suitable for a scientific journal. We have eventually decided to publish this "as is". We did this mostly because it was Peter's wish that this talk was published in this form and because we agreed with his notion that this format transmits the message just as well as a formal article as defined by our instructions for authors. We, the Editors, wish to make clear however that this is an exception that we made because we would like to preserve the temporal unity and message of this set of publications. Insisting on a formal publication would have meant losing this historical account as part of the thematic series of papers or disrupting the series. We hope that this will find the consent of our readership.

No MeSH data available.


Related in: MedlinePlus