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Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments.

Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, Rocha-Filho PA - J Nanobiotechnology (2011)

Bottom Line: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries.The nanoemulsion was stable over the time course of this study.The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. danibernardi81@yahoo.com.br

ABSTRACT

Background: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.

Results: The nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.

Conclusion: The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

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Moisturising variance after nanoemulsion treatment in volunteers with either normal skin or skin affected by atopic dermatitis or psoriasis.
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Figure 6: Moisturising variance after nanoemulsion treatment in volunteers with either normal skin or skin affected by atopic dermatitis or psoriasis.

Mentions: The moisturising activity of the stratum corneum is measured by skin capacitance. It is also an important tool in evaluating healthy and diseased skin such as patients with atopic dermatitis or psoriasis [34-36]. The moisturising variance in healthy volunteers increased both 30 and 60 minutes after nanoemulsion application and then decreased over the remainder of the study. Volunteers with atopic dermatitis or psoriasis showed increased moisturising variance in the first 30 minutes and maintained this increase up to 90 minutes after application. Then, the moisturising capacitance decreased after 90 minutes until the end of test (Figure 6). Skin affected by atopic dermatitis or psoriasis had a lower basal hydration value compared with healthy skin. People with these drying skin conditions have increased dryness in their skin outside of the regions with lesions [37-39]. The rice bran oil nanoemulsion increased the moisturising variance by about 38% in normal skin volunteers and by 30% in volunteers with atopic dermatitis or psoriasis, which is a satisfactory result because a high-quality commercial moisturiser only increased skin hydration by about 20% after 14 days of application [40]. These improved effects may be caused by the nanoemulsion droplets adhering to the skin and forming a dense film that inhibits water evaporation from the skin [41].


Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments.

Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, Rocha-Filho PA - J Nanobiotechnology (2011)

Moisturising variance after nanoemulsion treatment in volunteers with either normal skin or skin affected by atopic dermatitis or psoriasis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198904&req=5

Figure 6: Moisturising variance after nanoemulsion treatment in volunteers with either normal skin or skin affected by atopic dermatitis or psoriasis.
Mentions: The moisturising activity of the stratum corneum is measured by skin capacitance. It is also an important tool in evaluating healthy and diseased skin such as patients with atopic dermatitis or psoriasis [34-36]. The moisturising variance in healthy volunteers increased both 30 and 60 minutes after nanoemulsion application and then decreased over the remainder of the study. Volunteers with atopic dermatitis or psoriasis showed increased moisturising variance in the first 30 minutes and maintained this increase up to 90 minutes after application. Then, the moisturising capacitance decreased after 90 minutes until the end of test (Figure 6). Skin affected by atopic dermatitis or psoriasis had a lower basal hydration value compared with healthy skin. People with these drying skin conditions have increased dryness in their skin outside of the regions with lesions [37-39]. The rice bran oil nanoemulsion increased the moisturising variance by about 38% in normal skin volunteers and by 30% in volunteers with atopic dermatitis or psoriasis, which is a satisfactory result because a high-quality commercial moisturiser only increased skin hydration by about 20% after 14 days of application [40]. These improved effects may be caused by the nanoemulsion droplets adhering to the skin and forming a dense film that inhibits water evaporation from the skin [41].

Bottom Line: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries.The nanoemulsion was stable over the time course of this study.The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. danibernardi81@yahoo.com.br

ABSTRACT

Background: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.

Results: The nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.

Conclusion: The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

Show MeSH
Related in: MedlinePlus