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Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments.

Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, Rocha-Filho PA - J Nanobiotechnology (2011)

Bottom Line: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries.The nanoemulsion was stable over the time course of this study.The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. danibernardi81@yahoo.com.br

ABSTRACT

Background: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.

Results: The nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.

Conclusion: The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

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Droplet size distribution of nanoemulsions after 24 hours.
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Figure 2: Droplet size distribution of nanoemulsions after 24 hours.

Mentions: The formulation composed of 10:10:80 (rice bran oil, surfactant blend and water) was supplemented with 0.05% antioxidants and 0.50% preservatives. The formulation was tested at three different storage temperatures: 25 ± 2°C, 40 ± 2°C and 5 ± 2°C. By granulometric analysis the particles maintained a mono-disperse, monomodal peak after 24 hours (Figure 2). The formulation was stable for up to 90 days as determined by macroscopic analysis.


Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments.

Bernardi DS, Pereira TA, Maciel NR, Bortoloto J, Viera GS, Oliveira GC, Rocha-Filho PA - J Nanobiotechnology (2011)

Droplet size distribution of nanoemulsions after 24 hours.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198904&req=5

Figure 2: Droplet size distribution of nanoemulsions after 24 hours.
Mentions: The formulation composed of 10:10:80 (rice bran oil, surfactant blend and water) was supplemented with 0.05% antioxidants and 0.50% preservatives. The formulation was tested at three different storage temperatures: 25 ± 2°C, 40 ± 2°C and 5 ± 2°C. By granulometric analysis the particles maintained a mono-disperse, monomodal peak after 24 hours (Figure 2). The formulation was stable for up to 90 days as determined by macroscopic analysis.

Bottom Line: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries.The nanoemulsion was stable over the time course of this study.The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil. danibernardi81@yahoo.com.br

ABSTRACT

Background: Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.

Results: The nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.

Conclusion: The results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

Show MeSH
Related in: MedlinePlus