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Development and reproducibility of a computed tomography-based measurement of renal sinus fat.

Foster MC, Hwang SJ, Porter SA, Massaro JM, Hoffmann U, Fox CS - BMC Nephrol (2011)

Bottom Line: Intra- and inter-reader intra-class correlation coefficients were 0.93 and 0.86, respectively.Similar correlations were observed for volumetric renal sinus fat in the right kidney.Measuring renal sinus fat is feasible and reproducible using MDCT scans in a community-based sample.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.

ABSTRACT

Background: Renal sinus fat may mediate obesity-related vascular disease, although this fat depot has not been assessed in a community-based sample. We sought to develop a protocol to quantify renal sinus fat accumulation using multi-detector computed tomography (MDCT).

Methods: Protocol development was performed in participants in the Framingham Offspring cohort who underwent MDCT. Volumetric renal sinus fat was measured separately within the right and left kidneys, and renal sinus fat area within a single MDCT scan slice was measured in the right kidney. Due to the high correlation of volumetric and single-slice renal sinus fat in the right kidney (Pearson correlation [r] = 0.85, p < 0.0001), we optimized a single-slice protocol to capture renal sinus fat in the right kidney alone. Pearson correlation coefficients were used to compare to assess the correlation of volumetric and single-slice renal sinus fat in the right kidney with other measures of adiposity. Inter- and intra-reader reproducibility was assessed using intra-class correlation coefficients.

Results: Single-slice measurements were obtained in 92 participants (mean age 60 years, 49% women, median renal sinus fat 0.43 cm2). Intra- and inter-reader intra-class correlation coefficients were 0.93 and 0.86, respectively. Single-slice renal sinus fat was correlated with body mass index (r = 0.35, p = 0.0006), waist circumference (r = 0.31, p = 0.003), and abdominal visceral fat (r = 0.48, p < 0.0001). Similar correlations were observed for volumetric renal sinus fat in the right kidney.

Conclusions: Measuring renal sinus fat is feasible and reproducible using MDCT scans in a community-based sample.

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Related in: MedlinePlus

Intra-reader and inter-reader single-slice renal sinus fat measurements. Renal sinus fat measures between one reader (A) and two readers (B) are plotted. Intra-reader intra-class correlation coefficient (ICC) = 0.93 and inter-reader ICC = 0.86.
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Figure 2: Intra-reader and inter-reader single-slice renal sinus fat measurements. Renal sinus fat measures between one reader (A) and two readers (B) are plotted. Intra-reader intra-class correlation coefficient (ICC) = 0.93 and inter-reader ICC = 0.86.

Mentions: Intra- and inter-reader renal fat measurements are plotted in Figures 2a and 2b, respectively. The intra-reader intra-class correlation coefficient was 0.93 and the inter-reader intra-class correlation coefficient was 0.86 for our single-slice measurement protocol.


Development and reproducibility of a computed tomography-based measurement of renal sinus fat.

Foster MC, Hwang SJ, Porter SA, Massaro JM, Hoffmann U, Fox CS - BMC Nephrol (2011)

Intra-reader and inter-reader single-slice renal sinus fat measurements. Renal sinus fat measures between one reader (A) and two readers (B) are plotted. Intra-reader intra-class correlation coefficient (ICC) = 0.93 and inter-reader ICC = 0.86.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198884&req=5

Figure 2: Intra-reader and inter-reader single-slice renal sinus fat measurements. Renal sinus fat measures between one reader (A) and two readers (B) are plotted. Intra-reader intra-class correlation coefficient (ICC) = 0.93 and inter-reader ICC = 0.86.
Mentions: Intra- and inter-reader renal fat measurements are plotted in Figures 2a and 2b, respectively. The intra-reader intra-class correlation coefficient was 0.93 and the inter-reader intra-class correlation coefficient was 0.86 for our single-slice measurement protocol.

Bottom Line: Intra- and inter-reader intra-class correlation coefficients were 0.93 and 0.86, respectively.Similar correlations were observed for volumetric renal sinus fat in the right kidney.Measuring renal sinus fat is feasible and reproducible using MDCT scans in a community-based sample.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.

ABSTRACT

Background: Renal sinus fat may mediate obesity-related vascular disease, although this fat depot has not been assessed in a community-based sample. We sought to develop a protocol to quantify renal sinus fat accumulation using multi-detector computed tomography (MDCT).

Methods: Protocol development was performed in participants in the Framingham Offspring cohort who underwent MDCT. Volumetric renal sinus fat was measured separately within the right and left kidneys, and renal sinus fat area within a single MDCT scan slice was measured in the right kidney. Due to the high correlation of volumetric and single-slice renal sinus fat in the right kidney (Pearson correlation [r] = 0.85, p < 0.0001), we optimized a single-slice protocol to capture renal sinus fat in the right kidney alone. Pearson correlation coefficients were used to compare to assess the correlation of volumetric and single-slice renal sinus fat in the right kidney with other measures of adiposity. Inter- and intra-reader reproducibility was assessed using intra-class correlation coefficients.

Results: Single-slice measurements were obtained in 92 participants (mean age 60 years, 49% women, median renal sinus fat 0.43 cm2). Intra- and inter-reader intra-class correlation coefficients were 0.93 and 0.86, respectively. Single-slice renal sinus fat was correlated with body mass index (r = 0.35, p = 0.0006), waist circumference (r = 0.31, p = 0.003), and abdominal visceral fat (r = 0.48, p < 0.0001). Similar correlations were observed for volumetric renal sinus fat in the right kidney.

Conclusions: Measuring renal sinus fat is feasible and reproducible using MDCT scans in a community-based sample.

Show MeSH
Related in: MedlinePlus