Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
Bottom Line: Since there is evidence that Mg(2+) modulates the hypothalamic-pituitary adrenal (HPA) axis, we tested whether enhanced anxiety-like behaviour can be reliably elicited by dietary Mg(2+) deficiency and whether Mg(2+) deficiency is associated with altered HPA axis function.It is further suggested that dysregulations in the HPA axis may contribute to the hyper-emotionality in response to dietary induced hypomagnesaemia.This article is part of a Special Issue entitled 'Anxiety and Depression'.
Affiliation: Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria. email@example.comShow MeSH
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Mentions: In an attempt to gain additional evidence for a possible functional relevance of increased PVN prepro-CRH mRNA expression in the Mg2+ deficiency-induced enhanced anxiety-related behaviour, c-Fos expression was used to map neuronal activation in the PVN in response to the mild emotional challenge of open arm exposure. As with the C57Bl/6N strain, Mg2+ deficiency increased anxiety-related behaviour in BALB/c mice which was reversed by diazepam treatment as indicated by significant dietary and drug effects in the measures “percentage of entries into the anxiogenic distal part of the open arm” (diet: F1,35 = 12.615, P < 0.01; drug: F1,35 = 15.359, P < 0.001, Table 4, Fig. 4A) and “total distance travelled” (diet: F1,35 = 6.120, P < 0.05; drug: F1,36 = 33.519, P < 0.001; Table 4). Furthermore, diazepam significantly affected the percentage of time spent in the distal compartment (F1,35 = 10.352, P < 0.01) (Table 4).
Affiliation: Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria. firstname.lastname@example.org