Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
Bottom Line: Since there is evidence that Mg(2+) modulates the hypothalamic-pituitary adrenal (HPA) axis, we tested whether enhanced anxiety-like behaviour can be reliably elicited by dietary Mg(2+) deficiency and whether Mg(2+) deficiency is associated with altered HPA axis function.It is further suggested that dysregulations in the HPA axis may contribute to the hyper-emotionality in response to dietary induced hypomagnesaemia.This article is part of a Special Issue entitled 'Anxiety and Depression'.
Affiliation: Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria. email@example.comShow MeSH
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Mentions: In C57Bl/6N mice prepro-CRH mRNA expression, as visualised by in situ hybridisation, was high in the PVN and moderate in the central amygdala and Barrington’s nucleus (Table 2), which is in good accordance with previous studies (e.g. Keegan et al., 1994). In the PVN a significant group effect was observed (F2,29 = 12.486, P < 0.001) as the abundance of prepro-CRH mRNA was increased in Mg2+ deficient mice compared with mice fed the control diet (P < 0.001), and chronic treatment with desipramine normalised this effect in Mg2+ deficient mice (P < 0.001) (Table 2, Fig. 3). In contrast to the PVN, prepro-CRH mRNA expression did not differ between experimental groups in the central amygdala (n.s.) or in the Barrington’s nucleus (n.s.) (Table 2).
Affiliation: Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria. firstname.lastname@example.org