Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment.
Bottom Line: Since there is evidence that Mg(2+) modulates the hypothalamic-pituitary adrenal (HPA) axis, we tested whether enhanced anxiety-like behaviour can be reliably elicited by dietary Mg(2+) deficiency and whether Mg(2+) deficiency is associated with altered HPA axis function.It is further suggested that dysregulations in the HPA axis may contribute to the hyper-emotionality in response to dietary induced hypomagnesaemia.This article is part of a Special Issue entitled 'Anxiety and Depression'.
Affiliation: Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria. email@example.comShow MeSH
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Mentions: Next, we subjected all C57Bl/6N mice to the hyponeophagia paradigm, one of the few tests which are sensitive to the anxiolytic effects of chronic antidepressant treatment (Bodnoff et al., 1989; Dulawa and Hen, 2005; Gordon and Hen, 2004). There was a significant group effect in the latency to eat (F3,58 = 11.828, P < 0.001) the preferred food placed into the centre of the testing arena (Fig. 2). Mg2+ deficiency caused an increase in the latency to eat. In Mg2+ deficient mice chronic desipramine treatment reduced the latency to eat compared with untreated mice while long-term treatment with paroxetine did not affect this behavioural parameter (Fig. 2). Mg2+ deficiency and long-term antidepressant treatments did not alter general locomotor activity as indicated by the distances travelled in the open field test (n.s.; Table 1), the light/dark test (n.s.; Table 1), and the hyponeophagia test (n.s.; Fig. 2). All together these findings suggest that chronic Mg2+ deficiency was anxiogenic and that chronic desipramine, but not paroxetine treatment was effective in reducing anxiety in this model.
Affiliation: Department of Pharmacology and Toxicology, Institute of Pharmacy, and Centre for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Peter-Mayr-Strasse 1, A-6020 Innsbruck, Austria. firstname.lastname@example.org