Neural circuits underlying adaptation and learning in the perception of auditory space.
Bottom Line: Sound localization mechanisms are particularly plastic during development, when the monaural and binaural acoustic cues that form the basis for spatial hearing change in value as the body grows.Recent studies have shown that the mature brain retains a surprising capacity to relearn to localize sound in the presence of substantially altered auditory spatial cues.Through a combination of recording studies and methods for selectively manipulating the activity of specific neuronal populations, progress is now being made in identifying the cortical and subcortical circuits in the brain that are responsible for the dynamic coding of auditory spatial information.
Affiliation: Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK. firstname.lastname@example.orgShow MeSH
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Mentions: Although a reduced ability to localize sound results when A1 alone is silenced, larger deficits are observed when surrounding auditory cortical areas are affected as well (Fig. 3), suggesting that different parts of the auditory cortex are required for the processing of spatial information. Indeed, there is both physiological (Harrington et al., 2008; Miller and Recanzone, 2009; Bizley and King, 2011) and behavioral (Malhotra et al., 2008) evidence that certain non-primary areas make larger contributions to sound localization. Exactly how the cortex underpins the perception of auditory space remains uncertain, but the failure to find a topographic representation equivalent to that present in the SC (Palmer and King, 1982) has prompted the idea that sound-source location is encoded by the spatial distribution of activity across populations of cortical neurons (Miller and Recanzone, 2009; Stecker et al., 2005).
Affiliation: Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK. email@example.com