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Event-related potential correlates of performance-monitoring in a lateralized time-estimation task.

Gruendler TO, Ullsperger M, Huster RJ - PLoS ONE (2011)

Bottom Line: Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs.The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal.Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Neurology, Max Planck Institute for Neurological Research, Cologne, Germany. theo@gruendler.de

ABSTRACT
Performance-monitoring as a key function of cognitive control covers a wide range of diverse processes to enable goal directed behavior and to avoid maladjustments. Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs. For example, the feedback-related negativity (FRN) is associated with unexpected performance feedback and might serve as a teaching signal for adaptational processes, whereas the error-related negativity (ERN) is associated with error commission and subsequent behavioral adaptation. The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal. Here, we present an innovative paradigm to concurrently study these different performance-monitoring-related ERPs. In 24 participants a tactile time-estimation task interspersed with infrequent stop-signal trials reliably elicited all three ERPs. Sensory input and motor output were completely lateralized, in order to estimate any hemispheric processing preferences for the different aspects of performance monitoring associated with these ERPs. In accordance with the literature our data suggest augmented inhibitory capabilities in the right hemisphere given that stop-trial performance was significantly better with left- as compared to right-hand stop-signals. In line with this, the N2 scalp distribution was generally shifted to the right in addition to an ipsilateral shift in relation to the response hand. Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN. Comparing the ERP topographies using the Global Map Dissimilarity index, a large topographic overlap was found between all considered components.With an evenly distributed set of trials and a split-half reliability for all ERP components ≥.85 the task is well suited to efficiently study N2, ERN, and FRN concurrently which might prove useful for group comparisons, especially in clinical populations.

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Regression analyses between FRN, N2, and ERN.Peak amplitudes of the ERPs were z-normalized. Bivariate regression analyses between the N2 and ERN revealed a strong relationship (β = .755; SEM = .140; t = 5.407; p<.001) between the N2 and ERN, and much less shared variance between the N2 and FRN (β = .426; SEM = .193; t = 2.21; p = .038). Coefficents of the bivariate regression between ERN and FRN are in between the aforementioned ones (β = .553; SEM = .178; t = 3.11; p = .005).
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pone-0025591-g007: Regression analyses between FRN, N2, and ERN.Peak amplitudes of the ERPs were z-normalized. Bivariate regression analyses between the N2 and ERN revealed a strong relationship (β = .755; SEM = .140; t = 5.407; p<.001) between the N2 and ERN, and much less shared variance between the N2 and FRN (β = .426; SEM = .193; t = 2.21; p = .038). Coefficents of the bivariate regression between ERN and FRN are in between the aforementioned ones (β = .553; SEM = .178; t = 3.11; p = .005).

Mentions: Bivariate regression analyses between the z-normalized peak amplitudes of the three components revealed strong associations between the FRN, N2, and ERN amplitudes. The relationship between the amplitudes of the N2 and ERN was strongest (β = .755; SEM = .140; t = 5.407; p>.001; R2 = .571), whereas the relationship between the N2 and FRN was much weaker (β = .426; SEM = .193; t = 2.21; p = .038; R2 = .181). The relationship between ERN and FRN amplitudes was in between (β = .553; SEM = .178; t = 3.111; p = .005; R2 = .306). These results are also depicted in Figure 7.


Event-related potential correlates of performance-monitoring in a lateralized time-estimation task.

Gruendler TO, Ullsperger M, Huster RJ - PLoS ONE (2011)

Regression analyses between FRN, N2, and ERN.Peak amplitudes of the ERPs were z-normalized. Bivariate regression analyses between the N2 and ERN revealed a strong relationship (β = .755; SEM = .140; t = 5.407; p<.001) between the N2 and ERN, and much less shared variance between the N2 and FRN (β = .426; SEM = .193; t = 2.21; p = .038). Coefficents of the bivariate regression between ERN and FRN are in between the aforementioned ones (β = .553; SEM = .178; t = 3.11; p = .005).
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3198451&req=5

pone-0025591-g007: Regression analyses between FRN, N2, and ERN.Peak amplitudes of the ERPs were z-normalized. Bivariate regression analyses between the N2 and ERN revealed a strong relationship (β = .755; SEM = .140; t = 5.407; p<.001) between the N2 and ERN, and much less shared variance between the N2 and FRN (β = .426; SEM = .193; t = 2.21; p = .038). Coefficents of the bivariate regression between ERN and FRN are in between the aforementioned ones (β = .553; SEM = .178; t = 3.11; p = .005).
Mentions: Bivariate regression analyses between the z-normalized peak amplitudes of the three components revealed strong associations between the FRN, N2, and ERN amplitudes. The relationship between the amplitudes of the N2 and ERN was strongest (β = .755; SEM = .140; t = 5.407; p>.001; R2 = .571), whereas the relationship between the N2 and FRN was much weaker (β = .426; SEM = .193; t = 2.21; p = .038; R2 = .181). The relationship between ERN and FRN amplitudes was in between (β = .553; SEM = .178; t = 3.111; p = .005; R2 = .306). These results are also depicted in Figure 7.

Bottom Line: Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs.The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal.Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Neurology, Max Planck Institute for Neurological Research, Cologne, Germany. theo@gruendler.de

ABSTRACT
Performance-monitoring as a key function of cognitive control covers a wide range of diverse processes to enable goal directed behavior and to avoid maladjustments. Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs. For example, the feedback-related negativity (FRN) is associated with unexpected performance feedback and might serve as a teaching signal for adaptational processes, whereas the error-related negativity (ERN) is associated with error commission and subsequent behavioral adaptation. The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal. Here, we present an innovative paradigm to concurrently study these different performance-monitoring-related ERPs. In 24 participants a tactile time-estimation task interspersed with infrequent stop-signal trials reliably elicited all three ERPs. Sensory input and motor output were completely lateralized, in order to estimate any hemispheric processing preferences for the different aspects of performance monitoring associated with these ERPs. In accordance with the literature our data suggest augmented inhibitory capabilities in the right hemisphere given that stop-trial performance was significantly better with left- as compared to right-hand stop-signals. In line with this, the N2 scalp distribution was generally shifted to the right in addition to an ipsilateral shift in relation to the response hand. Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN. Comparing the ERP topographies using the Global Map Dissimilarity index, a large topographic overlap was found between all considered components.With an evenly distributed set of trials and a split-half reliability for all ERP components ≥.85 the task is well suited to efficiently study N2, ERN, and FRN concurrently which might prove useful for group comparisons, especially in clinical populations.

Show MeSH
Related in: MedlinePlus