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Event-related potential correlates of performance-monitoring in a lateralized time-estimation task.

Gruendler TO, Ullsperger M, Huster RJ - PLoS ONE (2011)

Bottom Line: Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs.The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal.Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Neurology, Max Planck Institute for Neurological Research, Cologne, Germany. theo@gruendler.de

ABSTRACT
Performance-monitoring as a key function of cognitive control covers a wide range of diverse processes to enable goal directed behavior and to avoid maladjustments. Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs. For example, the feedback-related negativity (FRN) is associated with unexpected performance feedback and might serve as a teaching signal for adaptational processes, whereas the error-related negativity (ERN) is associated with error commission and subsequent behavioral adaptation. The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal. Here, we present an innovative paradigm to concurrently study these different performance-monitoring-related ERPs. In 24 participants a tactile time-estimation task interspersed with infrequent stop-signal trials reliably elicited all three ERPs. Sensory input and motor output were completely lateralized, in order to estimate any hemispheric processing preferences for the different aspects of performance monitoring associated with these ERPs. In accordance with the literature our data suggest augmented inhibitory capabilities in the right hemisphere given that stop-trial performance was significantly better with left- as compared to right-hand stop-signals. In line with this, the N2 scalp distribution was generally shifted to the right in addition to an ipsilateral shift in relation to the response hand. Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN. Comparing the ERP topographies using the Global Map Dissimilarity index, a large topographic overlap was found between all considered components.With an evenly distributed set of trials and a split-half reliability for all ERP components ≥.85 the task is well suited to efficiently study N2, ERN, and FRN concurrently which might prove useful for group comparisons, especially in clinical populations.

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ERP data associated with performance-feedback in the time-estimation task (FRN).A: Scalp topographies for the left and right hand unexpected difference wave FRN peaks and histogram of the Global Map Dissimilarity permutation test between these two topographies. B; SWARM solution for the FRN revealing an aMCC source. C: Difference wave for expected and unexpected outcomes as observed at channel FCz. Tactile performance feedback was received at 0 on the abscissa. Note that negative voltages are plotted upwards by convention.
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pone-0025591-g003: ERP data associated with performance-feedback in the time-estimation task (FRN).A: Scalp topographies for the left and right hand unexpected difference wave FRN peaks and histogram of the Global Map Dissimilarity permutation test between these two topographies. B; SWARM solution for the FRN revealing an aMCC source. C: Difference wave for expected and unexpected outcomes as observed at channel FCz. Tactile performance feedback was received at 0 on the abscissa. Note that negative voltages are plotted upwards by convention.

Mentions: To trace their main generators inverse calculations for the three ERPs of interest (FRN, N2, ERN), averaged across hands and subjects, were computed. Anatomical landmarks (nasion, left and right preauricular points) were used to coregister the electrode positions of one elected subject to its structural MRI. A three-compartment boundary element model was computed for this participant. The resolution of the meshes was set to 9, 8 and 6 mm for skin, skull and brain, respectively. Standard conductivity values for the three compartments were set to: skin = 0.33 S/m, skull = 0.0042 S/m, brain = 0.33 S/m. After gray matter segmentation of the brain, a representation of the cortex excluding the brainstem and cerebellum was computed to limit the source space for the inverse solution. Current density reconstructions (CDR) were calculated using the SWARM method [56], which belongs to the family of weighted minimum norm solutions with its weights being based on a previously computed sLORETA outcome. Figures 3, 4, and 5 exhibit the solutions averaged across data points of 20 ms intervals around the peak alongside the ERPs.


Event-related potential correlates of performance-monitoring in a lateralized time-estimation task.

Gruendler TO, Ullsperger M, Huster RJ - PLoS ONE (2011)

ERP data associated with performance-feedback in the time-estimation task (FRN).A: Scalp topographies for the left and right hand unexpected difference wave FRN peaks and histogram of the Global Map Dissimilarity permutation test between these two topographies. B; SWARM solution for the FRN revealing an aMCC source. C: Difference wave for expected and unexpected outcomes as observed at channel FCz. Tactile performance feedback was received at 0 on the abscissa. Note that negative voltages are plotted upwards by convention.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3198451&req=5

pone-0025591-g003: ERP data associated with performance-feedback in the time-estimation task (FRN).A: Scalp topographies for the left and right hand unexpected difference wave FRN peaks and histogram of the Global Map Dissimilarity permutation test between these two topographies. B; SWARM solution for the FRN revealing an aMCC source. C: Difference wave for expected and unexpected outcomes as observed at channel FCz. Tactile performance feedback was received at 0 on the abscissa. Note that negative voltages are plotted upwards by convention.
Mentions: To trace their main generators inverse calculations for the three ERPs of interest (FRN, N2, ERN), averaged across hands and subjects, were computed. Anatomical landmarks (nasion, left and right preauricular points) were used to coregister the electrode positions of one elected subject to its structural MRI. A three-compartment boundary element model was computed for this participant. The resolution of the meshes was set to 9, 8 and 6 mm for skin, skull and brain, respectively. Standard conductivity values for the three compartments were set to: skin = 0.33 S/m, skull = 0.0042 S/m, brain = 0.33 S/m. After gray matter segmentation of the brain, a representation of the cortex excluding the brainstem and cerebellum was computed to limit the source space for the inverse solution. Current density reconstructions (CDR) were calculated using the SWARM method [56], which belongs to the family of weighted minimum norm solutions with its weights being based on a previously computed sLORETA outcome. Figures 3, 4, and 5 exhibit the solutions averaged across data points of 20 ms intervals around the peak alongside the ERPs.

Bottom Line: Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs.The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal.Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN.

View Article: PubMed Central - PubMed

Affiliation: Cognitive Neurology, Max Planck Institute for Neurological Research, Cologne, Germany. theo@gruendler.de

ABSTRACT
Performance-monitoring as a key function of cognitive control covers a wide range of diverse processes to enable goal directed behavior and to avoid maladjustments. Several event-related brain potentials (ERP) are associated with performance-monitoring, but their conceptual background differs. For example, the feedback-related negativity (FRN) is associated with unexpected performance feedback and might serve as a teaching signal for adaptational processes, whereas the error-related negativity (ERN) is associated with error commission and subsequent behavioral adaptation. The N2 is visible in the EEG when the participant successfully inhibits a response following a cue and thereby adapts to a given stop-signal. Here, we present an innovative paradigm to concurrently study these different performance-monitoring-related ERPs. In 24 participants a tactile time-estimation task interspersed with infrequent stop-signal trials reliably elicited all three ERPs. Sensory input and motor output were completely lateralized, in order to estimate any hemispheric processing preferences for the different aspects of performance monitoring associated with these ERPs. In accordance with the literature our data suggest augmented inhibitory capabilities in the right hemisphere given that stop-trial performance was significantly better with left- as compared to right-hand stop-signals. In line with this, the N2 scalp distribution was generally shifted to the right in addition to an ipsilateral shift in relation to the response hand. Other than that, task lateralization affected neither behavior related to error and feedback processing nor ERN or FRN. Comparing the ERP topographies using the Global Map Dissimilarity index, a large topographic overlap was found between all considered components.With an evenly distributed set of trials and a split-half reliability for all ERP components ≥.85 the task is well suited to efficiently study N2, ERN, and FRN concurrently which might prove useful for group comparisons, especially in clinical populations.

Show MeSH
Related in: MedlinePlus