Limits...
Defining obesity cut-off points for migrant South Asians.

Gray LJ, Yates T, Davies MJ, Brady E, Webb DR, Sattar N, Khunti K - PLoS ONE (2011)

Bottom Line: For WC, derived cut-off points for South Asian males equivalent to 102 cm in White Europeans were 83.8 cm (95% CI 79.3 cm to 88.2 cm) for the glycaemia factor, 91.4 cm (95% CI 86.9 cm to 95.8 cm) for the lipid factor, and 99.3 cm (95% CI 93.3 cm to 105.2 cm) for the blood pressure factor.Lower ethnicity cut-off points were seen for females for both BMI and WC.Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

ABSTRACT

Background: Body mass index (BMI) and waist circumference (WC) are used to define cardiovascular and type 2 diabetes risk. We aimed to derive appropriate BMI and WC obesity cut-off points in a migrant South Asian population.

Methods: 4688 White Europeans and 1333 South Asians resident in the UK aged 40-75 years inclusive were screened for type 2 diabetes. Principal components analysis was used to derive a glycaemia, lipid, and a blood pressure factor. Regression models for each factor, adjusted for age and stratified by sex, were used to identify BMI and WC cut-off points in South Asians that correspond to those defined for White Europeans.

Findings: For South Asian males, derived BMI obesity cut-off points equivalent to 30.0 kg/m(2) in White Europeans were 22.6 kg/m(2) (95% Confidence Interval (95% CI) 20.7 kg/m(2) to 24.5 kg/m(2)) for the glycaemia factor, 26.0 kg/m(2) (95% CI 24.7 kg/m(2) to 27.3 kg/m(2)) for the lipid factor, and 28.4 kg/m(2) (95% CI 26.5 kg/m(2) to 30.4 kg/m(2)) for the blood pressure factor. For WC, derived cut-off points for South Asian males equivalent to 102 cm in White Europeans were 83.8 cm (95% CI 79.3 cm to 88.2 cm) for the glycaemia factor, 91.4 cm (95% CI 86.9 cm to 95.8 cm) for the lipid factor, and 99.3 cm (95% CI 93.3 cm to 105.2 cm) for the blood pressure factor. Lower ethnicity cut-off points were seen for females for both BMI and WC.

Conclusions: Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans. South Asian ethnicity could be considered as a similar level of risk as obesity (in White Europeans) for the development of type 2 diabetes.

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Relationship between glycaemia factor and BMI among White European and South Asian males.The glycaemia factor is the single summary variable derived from the principal components analysis using fasting glucose, 2 hour glucose and HbA1c.
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pone-0026464-g001: Relationship between glycaemia factor and BMI among White European and South Asian males.The glycaemia factor is the single summary variable derived from the principal components analysis using fasting glucose, 2 hour glucose and HbA1c.

Mentions: Table 2 shows the equivalent BMI obesity cut-off points for South Asians compared to White Europeans. For a BMI of 30 kg/m2 in White Europeans cut-off points for South Asian males were: glycaemia 22.6 kg/m2 (20.7 kg/m2 to 24.5 kg/m2); lipid 26.0 kg/m2 (24.7 kg/m2 to 27.3 kg/m2); blood pressure 28.4 kg/m2 (26.5 kg/m2 to 30.4 kg/m2). Similar obesity cut-off points were identified for females: glycaemia 21.5 kg/m2 (19.5 kg/m2 to 23.5 kg/m2); lipid 23.9 kg/m2 (22.0 kg/m2 to 25.7 kg/m2); blood pressure 29.1 kg/m2 (24.9 kg/m2 to 33.3 kg/m2). Figures 1 and 2 demonstrate how these cut-off points were calculated for the glycaemia factor in males and females. The figures for the lipid and blood pressure factors are given in the supporting information (Figures S1, S2, S3, S4).


Defining obesity cut-off points for migrant South Asians.

Gray LJ, Yates T, Davies MJ, Brady E, Webb DR, Sattar N, Khunti K - PLoS ONE (2011)

Relationship between glycaemia factor and BMI among White European and South Asian males.The glycaemia factor is the single summary variable derived from the principal components analysis using fasting glucose, 2 hour glucose and HbA1c.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3198431&req=5

pone-0026464-g001: Relationship between glycaemia factor and BMI among White European and South Asian males.The glycaemia factor is the single summary variable derived from the principal components analysis using fasting glucose, 2 hour glucose and HbA1c.
Mentions: Table 2 shows the equivalent BMI obesity cut-off points for South Asians compared to White Europeans. For a BMI of 30 kg/m2 in White Europeans cut-off points for South Asian males were: glycaemia 22.6 kg/m2 (20.7 kg/m2 to 24.5 kg/m2); lipid 26.0 kg/m2 (24.7 kg/m2 to 27.3 kg/m2); blood pressure 28.4 kg/m2 (26.5 kg/m2 to 30.4 kg/m2). Similar obesity cut-off points were identified for females: glycaemia 21.5 kg/m2 (19.5 kg/m2 to 23.5 kg/m2); lipid 23.9 kg/m2 (22.0 kg/m2 to 25.7 kg/m2); blood pressure 29.1 kg/m2 (24.9 kg/m2 to 33.3 kg/m2). Figures 1 and 2 demonstrate how these cut-off points were calculated for the glycaemia factor in males and females. The figures for the lipid and blood pressure factors are given in the supporting information (Figures S1, S2, S3, S4).

Bottom Line: For WC, derived cut-off points for South Asian males equivalent to 102 cm in White Europeans were 83.8 cm (95% CI 79.3 cm to 88.2 cm) for the glycaemia factor, 91.4 cm (95% CI 86.9 cm to 95.8 cm) for the lipid factor, and 99.3 cm (95% CI 93.3 cm to 105.2 cm) for the blood pressure factor.Lower ethnicity cut-off points were seen for females for both BMI and WC.Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Sciences, University of Leicester, Leicester, United Kingdom.

ABSTRACT

Background: Body mass index (BMI) and waist circumference (WC) are used to define cardiovascular and type 2 diabetes risk. We aimed to derive appropriate BMI and WC obesity cut-off points in a migrant South Asian population.

Methods: 4688 White Europeans and 1333 South Asians resident in the UK aged 40-75 years inclusive were screened for type 2 diabetes. Principal components analysis was used to derive a glycaemia, lipid, and a blood pressure factor. Regression models for each factor, adjusted for age and stratified by sex, were used to identify BMI and WC cut-off points in South Asians that correspond to those defined for White Europeans.

Findings: For South Asian males, derived BMI obesity cut-off points equivalent to 30.0 kg/m(2) in White Europeans were 22.6 kg/m(2) (95% Confidence Interval (95% CI) 20.7 kg/m(2) to 24.5 kg/m(2)) for the glycaemia factor, 26.0 kg/m(2) (95% CI 24.7 kg/m(2) to 27.3 kg/m(2)) for the lipid factor, and 28.4 kg/m(2) (95% CI 26.5 kg/m(2) to 30.4 kg/m(2)) for the blood pressure factor. For WC, derived cut-off points for South Asian males equivalent to 102 cm in White Europeans were 83.8 cm (95% CI 79.3 cm to 88.2 cm) for the glycaemia factor, 91.4 cm (95% CI 86.9 cm to 95.8 cm) for the lipid factor, and 99.3 cm (95% CI 93.3 cm to 105.2 cm) for the blood pressure factor. Lower ethnicity cut-off points were seen for females for both BMI and WC.

Conclusions: Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans. South Asian ethnicity could be considered as a similar level of risk as obesity (in White Europeans) for the development of type 2 diabetes.

Show MeSH
Related in: MedlinePlus