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Safety, efficacy, and intraoperative characteristics of DisCoVisc and Healon ophthalmic viscosurgical devices for cataract surgery.

Modi SS, Davison JA, Walters T - Clin Ophthalmol (2011)

Bottom Line: To evaluate the safety and efficacy of DisCoVisc ophthalmic viscosurgical device (OVD, Alcon Laboratories, Inc) with respect to a comparator, Healon OVD (Advanced Medical Optics, Inc).Masked technicians evaluated objective safety parameters of intraocular pressure (IOP) and endothelial cell density, with 90 days of follow-up.DisCoVisc OVD had both cohesive and dispersive properties, and was safe and effective for every stage of cataract surgery.

View Article: PubMed Central - PubMed

Affiliation: Seeta Eye Centers, Poughkeepsie, NY, USA. smodieyes@aol.com

ABSTRACT

Purpose: To evaluate the safety and efficacy of DisCoVisc ophthalmic viscosurgical device (OVD, Alcon Laboratories, Inc) with respect to a comparator, Healon OVD (Advanced Medical Optics, Inc).

Patients and methods: In this prospective study, patients with cataracts were randomized to an OVD, and then received phacoemulsification and injection of an intraocular lens. After each surgery, unmasked investigators completed subjective questionnaires about OVD characteristics during each stage of the procedure. Masked technicians evaluated objective safety parameters of intraocular pressure (IOP) and endothelial cell density, with 90 days of follow-up.

Results: The DisCoVisc OVD group (128 eyes) and the Healon OVD group (121 eyes) had statistically similar outcomes for IOP and for endothelial cell loss. Subjectively assessed viscosity was statistically different (P < 0.0001), with Healon OVD most often rated "cohesive" and DisCoVisc OVD most often rated "both dispersive and cohesive". Workspace maintenance differed between groups (P < 0.0001), with workspace most frequently rated "full chamber maintained" when using DisCoVisc OVD and most frequently rated "workspace maintained" when using Healon OVD. "Flat" or "shallow" workspace ratings occurred only in the Healon OVD group.

Conclusion: DisCoVisc OVD had both cohesive and dispersive properties, and was safe and effective for every stage of cataract surgery.

No MeSH data available.


Related in: MedlinePlus

Space-maintaining characteristics of the ophthalmological viscosurgical devices (OVDs) during three surgical stages. Results are from nine surgeons assessing 121 Healon OVD cases (shown in red) and 128 DisCoVisc OVD cases (shown in blue).
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f4-opth-5-1381: Space-maintaining characteristics of the ophthalmological viscosurgical devices (OVDs) during three surgical stages. Results are from nine surgeons assessing 121 Healon OVD cases (shown in red) and 128 DisCoVisc OVD cases (shown in blue).

Mentions: Space-maintaining characteristics of the OVDs, as assessed subjectively by the nine surgeons, are shown for three surgical stages in Figure 4. When using the DisCoVisc OVD, surgeons most frequently rated the workspace as “full chamber maintained” during each surgical stage: 81% of cases during capsulorhexis, 78% of cases during phacoemulsification, and 87% of cases during IOL insertion. When using the Healon OVD, surgeons most frequently rated workspace as “workspace maintained” during each surgical stage: 37% of cases during capsulorhexis, 48% of cases during phacoemulsification, and 49% of cases during IOL insertion. No cases were rated as having “flat” or “shallow” workspaces during any of the three surgical stages when using the DisCoVisc OVD, but those ratings were given to Healon OVD cases in 32% of anterior capsulotomies, in 23% of phacoemulsification stages, and in 3% of IOL insertions. During all three surgical stages, the characterizations of space maintenance by the OVDs were statistically different between OVD groups (P < 0.0001 by Cochran–Mantel–Haenszel test).


Safety, efficacy, and intraoperative characteristics of DisCoVisc and Healon ophthalmic viscosurgical devices for cataract surgery.

Modi SS, Davison JA, Walters T - Clin Ophthalmol (2011)

Space-maintaining characteristics of the ophthalmological viscosurgical devices (OVDs) during three surgical stages. Results are from nine surgeons assessing 121 Healon OVD cases (shown in red) and 128 DisCoVisc OVD cases (shown in blue).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3198411&req=5

f4-opth-5-1381: Space-maintaining characteristics of the ophthalmological viscosurgical devices (OVDs) during three surgical stages. Results are from nine surgeons assessing 121 Healon OVD cases (shown in red) and 128 DisCoVisc OVD cases (shown in blue).
Mentions: Space-maintaining characteristics of the OVDs, as assessed subjectively by the nine surgeons, are shown for three surgical stages in Figure 4. When using the DisCoVisc OVD, surgeons most frequently rated the workspace as “full chamber maintained” during each surgical stage: 81% of cases during capsulorhexis, 78% of cases during phacoemulsification, and 87% of cases during IOL insertion. When using the Healon OVD, surgeons most frequently rated workspace as “workspace maintained” during each surgical stage: 37% of cases during capsulorhexis, 48% of cases during phacoemulsification, and 49% of cases during IOL insertion. No cases were rated as having “flat” or “shallow” workspaces during any of the three surgical stages when using the DisCoVisc OVD, but those ratings were given to Healon OVD cases in 32% of anterior capsulotomies, in 23% of phacoemulsification stages, and in 3% of IOL insertions. During all three surgical stages, the characterizations of space maintenance by the OVDs were statistically different between OVD groups (P < 0.0001 by Cochran–Mantel–Haenszel test).

Bottom Line: To evaluate the safety and efficacy of DisCoVisc ophthalmic viscosurgical device (OVD, Alcon Laboratories, Inc) with respect to a comparator, Healon OVD (Advanced Medical Optics, Inc).Masked technicians evaluated objective safety parameters of intraocular pressure (IOP) and endothelial cell density, with 90 days of follow-up.DisCoVisc OVD had both cohesive and dispersive properties, and was safe and effective for every stage of cataract surgery.

View Article: PubMed Central - PubMed

Affiliation: Seeta Eye Centers, Poughkeepsie, NY, USA. smodieyes@aol.com

ABSTRACT

Purpose: To evaluate the safety and efficacy of DisCoVisc ophthalmic viscosurgical device (OVD, Alcon Laboratories, Inc) with respect to a comparator, Healon OVD (Advanced Medical Optics, Inc).

Patients and methods: In this prospective study, patients with cataracts were randomized to an OVD, and then received phacoemulsification and injection of an intraocular lens. After each surgery, unmasked investigators completed subjective questionnaires about OVD characteristics during each stage of the procedure. Masked technicians evaluated objective safety parameters of intraocular pressure (IOP) and endothelial cell density, with 90 days of follow-up.

Results: The DisCoVisc OVD group (128 eyes) and the Healon OVD group (121 eyes) had statistically similar outcomes for IOP and for endothelial cell loss. Subjectively assessed viscosity was statistically different (P < 0.0001), with Healon OVD most often rated "cohesive" and DisCoVisc OVD most often rated "both dispersive and cohesive". Workspace maintenance differed between groups (P < 0.0001), with workspace most frequently rated "full chamber maintained" when using DisCoVisc OVD and most frequently rated "workspace maintained" when using Healon OVD. "Flat" or "shallow" workspace ratings occurred only in the Healon OVD group.

Conclusion: DisCoVisc OVD had both cohesive and dispersive properties, and was safe and effective for every stage of cataract surgery.

No MeSH data available.


Related in: MedlinePlus