Limits...
Measurement of ocular surface protection under natural blink conditions.

Abelson R, Lane KJ, Angjeli E, Johnston P, Ousler G, Montgomery D - Clin Ophthalmol (2011)

Bottom Line: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately.TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects.The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

View Article: PubMed Central - PubMed

Affiliation: Arizona State University, Tempe, AZ, USA. rabelson@sdcclinical.com

ABSTRACT

Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA).

Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution.

Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects.

Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

No MeSH data available.


Related in: MedlinePlus

Interblink interval observations for new (VCMA) and traditional (FS) methods for 17 dry-eye subjects (34 eyes). (A) Observed (yellow) and modeled (blue, lognormal) histogram. (B) Scatter plot of the new versus traditional observations relative to a 45° reference line. Sample means were 5.5 for VCMA and 4.0 for FS.Abbreviations: FS, forced-stare; SD, standard deviation; VCMA, video capture manual analysis.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3198408&req=5

f3-opth-5-1349: Interblink interval observations for new (VCMA) and traditional (FS) methods for 17 dry-eye subjects (34 eyes). (A) Observed (yellow) and modeled (blue, lognormal) histogram. (B) Scatter plot of the new versus traditional observations relative to a 45° reference line. Sample means were 5.5 for VCMA and 4.0 for FS.Abbreviations: FS, forced-stare; SD, standard deviation; VCMA, video capture manual analysis.

Mentions: Table 2 shows the IBI data from the traditional (FS) and the new (VCMA) methods for the 17 dry-eye subjects. The mean IBIs for the traditional (FS) and new (VCMA) methods were 4.04 and 5.51 seconds, respectively, for a ratio of 1.36 (P = 0.043). Figure 3 shows histograms for both methods and a scatter plot for individual data points.


Measurement of ocular surface protection under natural blink conditions.

Abelson R, Lane KJ, Angjeli E, Johnston P, Ousler G, Montgomery D - Clin Ophthalmol (2011)

Interblink interval observations for new (VCMA) and traditional (FS) methods for 17 dry-eye subjects (34 eyes). (A) Observed (yellow) and modeled (blue, lognormal) histogram. (B) Scatter plot of the new versus traditional observations relative to a 45° reference line. Sample means were 5.5 for VCMA and 4.0 for FS.Abbreviations: FS, forced-stare; SD, standard deviation; VCMA, video capture manual analysis.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3198408&req=5

f3-opth-5-1349: Interblink interval observations for new (VCMA) and traditional (FS) methods for 17 dry-eye subjects (34 eyes). (A) Observed (yellow) and modeled (blue, lognormal) histogram. (B) Scatter plot of the new versus traditional observations relative to a 45° reference line. Sample means were 5.5 for VCMA and 4.0 for FS.Abbreviations: FS, forced-stare; SD, standard deviation; VCMA, video capture manual analysis.
Mentions: Table 2 shows the IBI data from the traditional (FS) and the new (VCMA) methods for the 17 dry-eye subjects. The mean IBIs for the traditional (FS) and new (VCMA) methods were 4.04 and 5.51 seconds, respectively, for a ratio of 1.36 (P = 0.043). Figure 3 shows histograms for both methods and a scatter plot for individual data points.

Bottom Line: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately.TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects.The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

View Article: PubMed Central - PubMed

Affiliation: Arizona State University, Tempe, AZ, USA. rabelson@sdcclinical.com

ABSTRACT

Purpose: To evaluate a new method of measuring ocular exposure in the context of a natural blink pattern through analysis of the variables tear film breakup time (TFBUT), interblink interval (IBI), and tear film breakup area (BUA).

Methods: The traditional methodology (Forced-Stare [FS]) measures TFBUT and IBI separately. TFBUT is measured under forced-stare conditions by an examiner using a stopwatch, while IBI is measured as the subject watches television. The new methodology (video capture manual analysis [VCMA]) involves retrospective analysis of video data of fluorescein-stained eyes taken through a slit lamp while the subject watches television, and provides TFBUT and BUA for each IBI during the 1-minute video under natural blink conditions. The FS and VCMA methods were directly compared in the same set of dry-eye subjects. The VCMA method was evaluated for the ability to discriminate between dry-eye subjects and normal subjects. The VCMA method was further evaluated in the dry eye subjects for the ability to detect a treatment effect before, and 10 minutes after, bilateral instillation of an artificial tear solution.

Results: Ten normal subjects and 17 dry-eye subjects were studied. In the dry-eye subjects, the two methods differed with respect to mean TFBUTs (5.82 seconds, FS; 3.98 seconds, VCMA; P = 0.002). The FS variables alone (TFBUT, IBI) were not able to successfully distinguish between the dry-eye and normal subjects, whereas the additional VCMA variables, both derived and observed (BUA, BUA/IBI, breakup rate), were able to successfully distinguish between the dry-eye and normal subjects in a statistically significant fashion. TFBUT (P = 0.034) and BUA/IBI (P = 0.001) were able to distinguish the treatment effect of artificial tears in dry-eye subjects.

Conclusion: The VCMA methodology provides a clinically relevant analysis of tear film stability measured in the context of a natural blink pattern.

No MeSH data available.


Related in: MedlinePlus