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Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes.

Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P - Diabetes Care (2011)

Bottom Line: Diabetic subjects had greater vasoconstriction reactivity, more atrophy, depression, and slower walking.Regionally, sVCAM and sICAM were linked to exaggerated vasoconstriction, blunted vasodilatation, and increased cortical atrophy in the frontal, temporal, and parietal lobes (P = 0.04-0.003). sICAM correlated with worse functionality.Diabetes is associated with cortical atrophy, vasoconstriction, and worse performance.

View Article: PubMed Central - PubMed

Affiliation: Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. vnovak@bidmc.harvard.edu

ABSTRACT

Objective: To investigate the effects of inflammation on perfusion regulation and brain volumes in type 2 diabetes.

Research design and methods: A total of 147 subjects (71 diabetic and 76 nondiabetic, aged 65.2 ± 8 years) were studied using 3T anatomical and continuous arterial spin labeling magnetic resonance imaging. Analysis focused on the relationship between serum soluble vascular and intercellular adhesion molecules (sVCAM and sICAM, respectively, both markers of endothelial integrity), regional vasoreactivity, and tissue volumes.

Results: Diabetic subjects had greater vasoconstriction reactivity, more atrophy, depression, and slower walking. Adhesion molecules were specifically related to gray matter atrophy (P = 0.04) and altered vasoreactivity (P = 0.03) in the diabetic and control groups. Regionally, sVCAM and sICAM were linked to exaggerated vasoconstriction, blunted vasodilatation, and increased cortical atrophy in the frontal, temporal, and parietal lobes (P = 0.04-0.003). sICAM correlated with worse functionality.

Conclusions: Diabetes is associated with cortical atrophy, vasoconstriction, and worse performance. Adhesion molecules, as markers of vascular health, have been indicated to contribute to altered vasoregulation and atrophy.

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Related in: MedlinePlus

Relationships between adhesion molecules, regional brain volumes, and vasoreactivity: regional GM (A), WMHs (B), CO2VR-VD (C), and CO2VR-VC (D) in the diabetic (black bars) and control groups (white bars). The diabetic group as compared with the control group had lower regional GM volumes, greater WMH load, and exaggerated vasoconstriction reactivity. sVCAM was associated with lower GM volume in the temporal and parietal lobes (A) and decreased vasodilatation reactivity (C). sICAM was associated with lower GM volume in the frontal, temporal, and parietal lobes (A); blunted vasodilatation in the parietal and occipital lobes (C); and exaggerated vasoconstriction in the frontal, temporal, parietal, and occipital lobes (D) in the diabetic and control groups. WMHs were not related to adhesion molecules. sICAM: †P < 0.05, ††P < 0.01, †††P = 0.003. sVCAM: ‡P < 0.05. *P < 0.05, **P < 0.01, ***P < 0.0001 between group comparisons mean ± SE.
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Figure 1: Relationships between adhesion molecules, regional brain volumes, and vasoreactivity: regional GM (A), WMHs (B), CO2VR-VD (C), and CO2VR-VC (D) in the diabetic (black bars) and control groups (white bars). The diabetic group as compared with the control group had lower regional GM volumes, greater WMH load, and exaggerated vasoconstriction reactivity. sVCAM was associated with lower GM volume in the temporal and parietal lobes (A) and decreased vasodilatation reactivity (C). sICAM was associated with lower GM volume in the frontal, temporal, and parietal lobes (A); blunted vasodilatation in the parietal and occipital lobes (C); and exaggerated vasoconstriction in the frontal, temporal, parietal, and occipital lobes (D) in the diabetic and control groups. WMHs were not related to adhesion molecules. sICAM: †P < 0.05, ††P < 0.01, †††P = 0.003. sVCAM: ‡P < 0.05. *P < 0.05, **P < 0.01, ***P < 0.0001 between group comparisons mean ± SE.

Mentions: Diabetic subjects had lower GM volumes (parietal and occipital lobes and cerebellum, P < 0.02) (Fig. 1A) and greater WMH volume globally (P = 0.0004) and in the temporal, parietal, and occipital lobes (P < 0.01) (Fig. 1B). Baseline perfusion and CO2VR-VD were similar (Fig. 1C), yet the diabetic group had exaggerated CO2VR-VC in the frontal, parietal, and occipital regions (P < 0.01) (Fig. 1D).


Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes.

Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P - Diabetes Care (2011)

Relationships between adhesion molecules, regional brain volumes, and vasoreactivity: regional GM (A), WMHs (B), CO2VR-VD (C), and CO2VR-VC (D) in the diabetic (black bars) and control groups (white bars). The diabetic group as compared with the control group had lower regional GM volumes, greater WMH load, and exaggerated vasoconstriction reactivity. sVCAM was associated with lower GM volume in the temporal and parietal lobes (A) and decreased vasodilatation reactivity (C). sICAM was associated with lower GM volume in the frontal, temporal, and parietal lobes (A); blunted vasodilatation in the parietal and occipital lobes (C); and exaggerated vasoconstriction in the frontal, temporal, parietal, and occipital lobes (D) in the diabetic and control groups. WMHs were not related to adhesion molecules. sICAM: †P < 0.05, ††P < 0.01, †††P = 0.003. sVCAM: ‡P < 0.05. *P < 0.05, **P < 0.01, ***P < 0.0001 between group comparisons mean ± SE.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198286&req=5

Figure 1: Relationships between adhesion molecules, regional brain volumes, and vasoreactivity: regional GM (A), WMHs (B), CO2VR-VD (C), and CO2VR-VC (D) in the diabetic (black bars) and control groups (white bars). The diabetic group as compared with the control group had lower regional GM volumes, greater WMH load, and exaggerated vasoconstriction reactivity. sVCAM was associated with lower GM volume in the temporal and parietal lobes (A) and decreased vasodilatation reactivity (C). sICAM was associated with lower GM volume in the frontal, temporal, and parietal lobes (A); blunted vasodilatation in the parietal and occipital lobes (C); and exaggerated vasoconstriction in the frontal, temporal, parietal, and occipital lobes (D) in the diabetic and control groups. WMHs were not related to adhesion molecules. sICAM: †P < 0.05, ††P < 0.01, †††P = 0.003. sVCAM: ‡P < 0.05. *P < 0.05, **P < 0.01, ***P < 0.0001 between group comparisons mean ± SE.
Mentions: Diabetic subjects had lower GM volumes (parietal and occipital lobes and cerebellum, P < 0.02) (Fig. 1A) and greater WMH volume globally (P = 0.0004) and in the temporal, parietal, and occipital lobes (P < 0.01) (Fig. 1B). Baseline perfusion and CO2VR-VD were similar (Fig. 1C), yet the diabetic group had exaggerated CO2VR-VC in the frontal, parietal, and occipital regions (P < 0.01) (Fig. 1D).

Bottom Line: Diabetic subjects had greater vasoconstriction reactivity, more atrophy, depression, and slower walking.Regionally, sVCAM and sICAM were linked to exaggerated vasoconstriction, blunted vasodilatation, and increased cortical atrophy in the frontal, temporal, and parietal lobes (P = 0.04-0.003). sICAM correlated with worse functionality.Diabetes is associated with cortical atrophy, vasoconstriction, and worse performance.

View Article: PubMed Central - PubMed

Affiliation: Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. vnovak@bidmc.harvard.edu

ABSTRACT

Objective: To investigate the effects of inflammation on perfusion regulation and brain volumes in type 2 diabetes.

Research design and methods: A total of 147 subjects (71 diabetic and 76 nondiabetic, aged 65.2 ± 8 years) were studied using 3T anatomical and continuous arterial spin labeling magnetic resonance imaging. Analysis focused on the relationship between serum soluble vascular and intercellular adhesion molecules (sVCAM and sICAM, respectively, both markers of endothelial integrity), regional vasoreactivity, and tissue volumes.

Results: Diabetic subjects had greater vasoconstriction reactivity, more atrophy, depression, and slower walking. Adhesion molecules were specifically related to gray matter atrophy (P = 0.04) and altered vasoreactivity (P = 0.03) in the diabetic and control groups. Regionally, sVCAM and sICAM were linked to exaggerated vasoconstriction, blunted vasodilatation, and increased cortical atrophy in the frontal, temporal, and parietal lobes (P = 0.04-0.003). sICAM correlated with worse functionality.

Conclusions: Diabetes is associated with cortical atrophy, vasoconstriction, and worse performance. Adhesion molecules, as markers of vascular health, have been indicated to contribute to altered vasoregulation and atrophy.

Show MeSH
Related in: MedlinePlus