Limits...
Reducing rates of severe hypoglycemia in a population-based cohort of children and adolescents with type 1 diabetes over the decade 2000-2009.

O'Connell SM, Cooper MN, Bulsara MK, Davis EA, Jones TW - Diabetes Care (2011)

Bottom Line: A total of 7,378 patient-years of data and 780 SH events were recorded.The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006.HbA(1c) <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9-1.6], P = 0.29) compared with HbA(1c) of 8-9%.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia. tim.jones@health.wa.gov.au

ABSTRACT

Objective: To examine rates of severe hypoglycemia (SH) in a large population-based cohort of children with type 1 diabetes and relationships to HbA(1c).

Research design and methods: Data from 1,683 children (mean [SD] age at diagnosis 10.5 [4.2]; range 1-18 years) from 2000 to 2009 were analyzed from the Western Australian Children's Diabetes Database. Rates of SH were related to HbA(1c) using negative binomial regression.

Results: A total of 7,378 patient-years of data and 780 SH events were recorded. The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006. HbA(1c) <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9-1.6], P = 0.29) compared with HbA(1c) of 8-9%.

Conclusions: In a sample of youth with type 1 diabetes, there has been a decrease in rates of SH and a weaker relationship with glycemic control than previously observed.

Show MeSH

Related in: MedlinePlus

Rates of severe hypoglycemia by calendar year.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3198282&req=5

Figure 1: Rates of severe hypoglycemia by calendar year.

Mentions: The study included 1,683 children (51% boys). In total, 7,378 patient-years of data were available for analysis, and 780 SH events occurred during the decade. Of all patients, 77.4% had no episodes, 11.8% had one event, 5.2% had two events, and 5.6% had three or more episodes. The incidence rate for SH (Fig. 1), adjusted for age and sex, decreased by an average of 14% per year compared with previous year for the first 7 years (z = 5.33, P < 0.001) and did not change after that time (P = 0.446).


Reducing rates of severe hypoglycemia in a population-based cohort of children and adolescents with type 1 diabetes over the decade 2000-2009.

O'Connell SM, Cooper MN, Bulsara MK, Davis EA, Jones TW - Diabetes Care (2011)

Rates of severe hypoglycemia by calendar year.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198282&req=5

Figure 1: Rates of severe hypoglycemia by calendar year.
Mentions: The study included 1,683 children (51% boys). In total, 7,378 patient-years of data were available for analysis, and 780 SH events occurred during the decade. Of all patients, 77.4% had no episodes, 11.8% had one event, 5.2% had two events, and 5.6% had three or more episodes. The incidence rate for SH (Fig. 1), adjusted for age and sex, decreased by an average of 14% per year compared with previous year for the first 7 years (z = 5.33, P < 0.001) and did not change after that time (P = 0.446).

Bottom Line: A total of 7,378 patient-years of data and 780 SH events were recorded.The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006.HbA(1c) <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9-1.6], P = 0.29) compared with HbA(1c) of 8-9%.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Perth, Western Australia, Australia. tim.jones@health.wa.gov.au

ABSTRACT

Objective: To examine rates of severe hypoglycemia (SH) in a large population-based cohort of children with type 1 diabetes and relationships to HbA(1c).

Research design and methods: Data from 1,683 children (mean [SD] age at diagnosis 10.5 [4.2]; range 1-18 years) from 2000 to 2009 were analyzed from the Western Australian Children's Diabetes Database. Rates of SH were related to HbA(1c) using negative binomial regression.

Results: A total of 7,378 patient-years of data and 780 SH events were recorded. The rate of SH per 100 patient-years peaked at 17.3 in 2001 and then declined from 2004 to a nadir of 5.8 in 2006. HbA(1c) <7% was not associated with higher risk of SH (incidence rate ratio 1.2 [95% CI 0.9-1.6], P = 0.29) compared with HbA(1c) of 8-9%.

Conclusions: In a sample of youth with type 1 diabetes, there has been a decrease in rates of SH and a weaker relationship with glycemic control than previously observed.

Show MeSH
Related in: MedlinePlus