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Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer.

Jung SJ, Kim CI, Park CH, Chang HS, Kim BH, Choi MS, Jung HR - Korean J Urol (2011)

Bottom Line: Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041).Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041).The high expression of CXCR4 was associated with local recurrence and distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT

Purpose: We evaluated the correlation between the expression of CXCR4 and prognostic factors in patients with prostate cancer.

Materials and methods: A total of 57 patients who had undergone surgery for prostate cancer were enrolled. Specimens were obtained before any treatment and were stained with antihuman CXCR4 antibody. The intensity of staining was graded as low or high. The age, pretreatment prostate-specific antigen (PSA) level, Gleason score, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of CXCR4 in patients with prostate cancer.

Results: Local recurrence was higher in the group with high expression, in 11 of 36 cases (30.6%), than in the group with low expression, in 1 of 21 cases (4.8%), with statistical significance (p=0.040). Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041). In the logistic regression test, CXCR4 expression was the only factor in determining local recurrence (p=0.016) and distant metastasis (0.022). Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041). CXCR4 showed no association with age (p=0.881), pretreatment PSA level (p=0.584), Gleason score (p=0.640), T stage (p=0.967), or biochemical recurrence (p=0.081).

Conclusions: The high expression of CXCR4 was associated with local recurrence and distant metastasis. CXCR4 expression was shown to be a useful prognostic factor for patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus

Kaplan-Meier univariate survival analysis in patients with prostate cancer according to CXCR4 expression.
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Figure 2: Kaplan-Meier univariate survival analysis in patients with prostate cancer according to CXCR4 expression.

Mentions: Local recurrence of prostate cancer was higher in the group with high expression (30.6%, 11/36) than in the group with low expression (4.8%, 1/21; p=0.040). Distant metastasis was also associated with expression: it occurred in 27.8% (10/36) of the group with high expression and 4.8% (1/21) of the group with low expression (p=0.041). In the logistic regression analysis, CXCR4 expression was the only factor affecting local recurrence (p=0.016) and distant metastasis (p=0.022) among age, pretreatment PSA, Gleason score, and CXCR4. Furthermore, the high CXCR4 expression group showed significantly longer cancer-specific survival than did the low expression group (p=0.041) (Fig. 2).


Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer.

Jung SJ, Kim CI, Park CH, Chang HS, Kim BH, Choi MS, Jung HR - Korean J Urol (2011)

Kaplan-Meier univariate survival analysis in patients with prostate cancer according to CXCR4 expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3198233&req=5

Figure 2: Kaplan-Meier univariate survival analysis in patients with prostate cancer according to CXCR4 expression.
Mentions: Local recurrence of prostate cancer was higher in the group with high expression (30.6%, 11/36) than in the group with low expression (4.8%, 1/21; p=0.040). Distant metastasis was also associated with expression: it occurred in 27.8% (10/36) of the group with high expression and 4.8% (1/21) of the group with low expression (p=0.041). In the logistic regression analysis, CXCR4 expression was the only factor affecting local recurrence (p=0.016) and distant metastasis (p=0.022) among age, pretreatment PSA, Gleason score, and CXCR4. Furthermore, the high CXCR4 expression group showed significantly longer cancer-specific survival than did the low expression group (p=0.041) (Fig. 2).

Bottom Line: Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041).Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041).The high expression of CXCR4 was associated with local recurrence and distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT

Purpose: We evaluated the correlation between the expression of CXCR4 and prognostic factors in patients with prostate cancer.

Materials and methods: A total of 57 patients who had undergone surgery for prostate cancer were enrolled. Specimens were obtained before any treatment and were stained with antihuman CXCR4 antibody. The intensity of staining was graded as low or high. The age, pretreatment prostate-specific antigen (PSA) level, Gleason score, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of CXCR4 in patients with prostate cancer.

Results: Local recurrence was higher in the group with high expression, in 11 of 36 cases (30.6%), than in the group with low expression, in 1 of 21 cases (4.8%), with statistical significance (p=0.040). Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041). In the logistic regression test, CXCR4 expression was the only factor in determining local recurrence (p=0.016) and distant metastasis (0.022). Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041). CXCR4 showed no association with age (p=0.881), pretreatment PSA level (p=0.584), Gleason score (p=0.640), T stage (p=0.967), or biochemical recurrence (p=0.081).

Conclusions: The high expression of CXCR4 was associated with local recurrence and distant metastasis. CXCR4 expression was shown to be a useful prognostic factor for patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus