Limits...
Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer.

Jung SJ, Kim CI, Park CH, Chang HS, Kim BH, Choi MS, Jung HR - Korean J Urol (2011)

Bottom Line: Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041).Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041).The high expression of CXCR4 was associated with local recurrence and distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT

Purpose: We evaluated the correlation between the expression of CXCR4 and prognostic factors in patients with prostate cancer.

Materials and methods: A total of 57 patients who had undergone surgery for prostate cancer were enrolled. Specimens were obtained before any treatment and were stained with antihuman CXCR4 antibody. The intensity of staining was graded as low or high. The age, pretreatment prostate-specific antigen (PSA) level, Gleason score, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of CXCR4 in patients with prostate cancer.

Results: Local recurrence was higher in the group with high expression, in 11 of 36 cases (30.6%), than in the group with low expression, in 1 of 21 cases (4.8%), with statistical significance (p=0.040). Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041). In the logistic regression test, CXCR4 expression was the only factor in determining local recurrence (p=0.016) and distant metastasis (0.022). Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041). CXCR4 showed no association with age (p=0.881), pretreatment PSA level (p=0.584), Gleason score (p=0.640), T stage (p=0.967), or biochemical recurrence (p=0.081).

Conclusions: The high expression of CXCR4 was associated with local recurrence and distant metastasis. CXCR4 expression was shown to be a useful prognostic factor for patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus

CXCR4 expression in prostate cancer tissue (anti-CXCR4 antibody, ×200). (A) Low expression, (B) High expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
getmorefigures.php?uid=PMC3198233&req=5

Figure 1: CXCR4 expression in prostate cancer tissue (anti-CXCR4 antibody, ×200). (A) Low expression, (B) High expression.

Mentions: Two pathologists each interpreted the staining without prior knowledge of any of the clinicopathologic parameters. If the pathologists' analysis did not correspond, the staining was interpreted again. A judgement was made as to the proper immunohistochemical score of the tumors on the basis of the intensity of CXCR4 expression as follows: negative, weak, moderate, and strong staining. Samples with immunohistochemical scores of negative or weak were considered to have low expression and those with moderate to strong distributions were considered to have high expression of CXCR4 antibodies (Fig. 1).


Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer.

Jung SJ, Kim CI, Park CH, Chang HS, Kim BH, Choi MS, Jung HR - Korean J Urol (2011)

CXCR4 expression in prostate cancer tissue (anti-CXCR4 antibody, ×200). (A) Low expression, (B) High expression.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3198233&req=5

Figure 1: CXCR4 expression in prostate cancer tissue (anti-CXCR4 antibody, ×200). (A) Low expression, (B) High expression.
Mentions: Two pathologists each interpreted the staining without prior knowledge of any of the clinicopathologic parameters. If the pathologists' analysis did not correspond, the staining was interpreted again. A judgement was made as to the proper immunohistochemical score of the tumors on the basis of the intensity of CXCR4 expression as follows: negative, weak, moderate, and strong staining. Samples with immunohistochemical scores of negative or weak were considered to have low expression and those with moderate to strong distributions were considered to have high expression of CXCR4 antibodies (Fig. 1).

Bottom Line: Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041).Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041).The high expression of CXCR4 was associated with local recurrence and distant metastasis.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

ABSTRACT

Purpose: We evaluated the correlation between the expression of CXCR4 and prognostic factors in patients with prostate cancer.

Materials and methods: A total of 57 patients who had undergone surgery for prostate cancer were enrolled. Specimens were obtained before any treatment and were stained with antihuman CXCR4 antibody. The intensity of staining was graded as low or high. The age, pretreatment prostate-specific antigen (PSA) level, Gleason score, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of CXCR4 in patients with prostate cancer.

Results: Local recurrence was higher in the group with high expression, in 11 of 36 cases (30.6%), than in the group with low expression, in 1 of 21 cases (4.8%), with statistical significance (p=0.040). Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041). In the logistic regression test, CXCR4 expression was the only factor in determining local recurrence (p=0.016) and distant metastasis (0.022). Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041). CXCR4 showed no association with age (p=0.881), pretreatment PSA level (p=0.584), Gleason score (p=0.640), T stage (p=0.967), or biochemical recurrence (p=0.081).

Conclusions: The high expression of CXCR4 was associated with local recurrence and distant metastasis. CXCR4 expression was shown to be a useful prognostic factor for patients with prostate cancer.

No MeSH data available.


Related in: MedlinePlus