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Clinical significance of vasculogenic mimicry in human gliomas.

Liu XM, Zhang QP, Mu YG, Zhang XH, Sai K, Pang JC, Ng HK, Chen ZP - J. Neurooncol. (2011)

Bottom Line: We have previously found the presence of VM in high-grade gliomas.Vasculogenic mimicry channels were associated with the expression of COX-2 and MMP-9 (P < 0.05).Our results suggest that VM channels in gliomas correlate with increasing malignancy and higher aggressiveness, and may provide a complementation to the tumor's blood supply, especially in less vascularized regions, which may aid in the identification of glioma patients with a poorer prognosis.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Oncology in South China and Department of Neurosurgery/Neuro-Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

ABSTRACT
Vasculogenic mimicry (VM) is known as non-endothelial tumor cell-lined microvascular channels in aggressive tumors. We have previously found the presence of VM in high-grade gliomas. In this study, we aimed to identify VM patterns in gliomas and to explore their clinical significance. Tumor samples as well as their detailed clinical/prognostic data were collected from 101 patients. Vasculogenic mimicry in the glioma samples was determined by dual staining for endothelial marker CD34 and periodic acid-Schiff (PAS). Tumor samples were also immunohistochemically stained for Ki-67, VEGF, COX-2 and MMP-9. The association between VM and the clinical characteristics of the patients were analyzed. A Kaplan-Meier survival analysis and log-rank tests were performed to compare survival times of the patients. Vasculogenic mimicry was present in 13 out of 101 samples. The higher grade gliomas had a higher incidence of VM than that of lower grade gliomas (P = 0.006). Vasculogenic mimicry channels were associated with the expression of COX-2 and MMP-9 (P < 0.05). While there was no association between the existence of VM and the sex, age and preoperative epilepsy of the patients, or expression of Ki-67 and VEGF. However, patients with VM-positive gliomas survived a shorter period of time than those with VM negative gliomas (P = 0.027). Interestingly, in high-grade gliomas, the level of microvascular density was lower in VM positive tumors than those VM negative tumors (P = 0.039). Our results suggest that VM channels in gliomas correlate with increasing malignancy and higher aggressiveness, and may provide a complementation to the tumor's blood supply, especially in less vascularized regions, which may aid in the identification of glioma patients with a poorer prognosis.

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Patients whose tumors have VM show shorter survival than those without VM (P = 0.027) by Kaplan–Meier survival analysis
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Fig2: Patients whose tumors have VM show shorter survival than those without VM (P = 0.027) by Kaplan–Meier survival analysis

Mentions: Using the Kaplan–Meier survival analysis, we compared the survival times between patients with and without VM tumors. In patients with VM-positive gliomas, the median survival time was 15 months (95% CI, 2–28 months), compared with a median survival time of 38 months (95% CI, 25–50 months) for patients with VM-negative tumors (P = 0.027) (Fig. 2). Since survival in patients with brain tumors has been associated with several clinicopathological variables, we attempted to define the relative contribution of VM expression to survival. Expression of VM correlated significantly with postoperative survival by univariate analysis (P = 0.028). The age, KPS, and tumor histology also correlated with survival by univariate analysis. Multivariate analysis and cox proportional hazards model indicated that age and tumor grade were independent predictors of poor prognosis (P = 0.003 and P = 0.004, respectively) for glioma patients.Fig. 2


Clinical significance of vasculogenic mimicry in human gliomas.

Liu XM, Zhang QP, Mu YG, Zhang XH, Sai K, Pang JC, Ng HK, Chen ZP - J. Neurooncol. (2011)

Patients whose tumors have VM show shorter survival than those without VM (P = 0.027) by Kaplan–Meier survival analysis
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3198193&req=5

Fig2: Patients whose tumors have VM show shorter survival than those without VM (P = 0.027) by Kaplan–Meier survival analysis
Mentions: Using the Kaplan–Meier survival analysis, we compared the survival times between patients with and without VM tumors. In patients with VM-positive gliomas, the median survival time was 15 months (95% CI, 2–28 months), compared with a median survival time of 38 months (95% CI, 25–50 months) for patients with VM-negative tumors (P = 0.027) (Fig. 2). Since survival in patients with brain tumors has been associated with several clinicopathological variables, we attempted to define the relative contribution of VM expression to survival. Expression of VM correlated significantly with postoperative survival by univariate analysis (P = 0.028). The age, KPS, and tumor histology also correlated with survival by univariate analysis. Multivariate analysis and cox proportional hazards model indicated that age and tumor grade were independent predictors of poor prognosis (P = 0.003 and P = 0.004, respectively) for glioma patients.Fig. 2

Bottom Line: We have previously found the presence of VM in high-grade gliomas.Vasculogenic mimicry channels were associated with the expression of COX-2 and MMP-9 (P < 0.05).Our results suggest that VM channels in gliomas correlate with increasing malignancy and higher aggressiveness, and may provide a complementation to the tumor's blood supply, especially in less vascularized regions, which may aid in the identification of glioma patients with a poorer prognosis.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Oncology in South China and Department of Neurosurgery/Neuro-Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng Road East, Guangzhou, 510060, People's Republic of China.

ABSTRACT
Vasculogenic mimicry (VM) is known as non-endothelial tumor cell-lined microvascular channels in aggressive tumors. We have previously found the presence of VM in high-grade gliomas. In this study, we aimed to identify VM patterns in gliomas and to explore their clinical significance. Tumor samples as well as their detailed clinical/prognostic data were collected from 101 patients. Vasculogenic mimicry in the glioma samples was determined by dual staining for endothelial marker CD34 and periodic acid-Schiff (PAS). Tumor samples were also immunohistochemically stained for Ki-67, VEGF, COX-2 and MMP-9. The association between VM and the clinical characteristics of the patients were analyzed. A Kaplan-Meier survival analysis and log-rank tests were performed to compare survival times of the patients. Vasculogenic mimicry was present in 13 out of 101 samples. The higher grade gliomas had a higher incidence of VM than that of lower grade gliomas (P = 0.006). Vasculogenic mimicry channels were associated with the expression of COX-2 and MMP-9 (P < 0.05). While there was no association between the existence of VM and the sex, age and preoperative epilepsy of the patients, or expression of Ki-67 and VEGF. However, patients with VM-positive gliomas survived a shorter period of time than those with VM negative gliomas (P = 0.027). Interestingly, in high-grade gliomas, the level of microvascular density was lower in VM positive tumors than those VM negative tumors (P = 0.039). Our results suggest that VM channels in gliomas correlate with increasing malignancy and higher aggressiveness, and may provide a complementation to the tumor's blood supply, especially in less vascularized regions, which may aid in the identification of glioma patients with a poorer prognosis.

Show MeSH
Related in: MedlinePlus