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The effect of epidural administration of dexamethasone on postoperative pain: a randomized controlled study in radical subtotal gastrectomy.

Jo YY, Yoo JH, Kim HJ, Kil HK - Korean J Anesthesiol (2011)

Bottom Line: VAS and requirements of rescue analgesics were significantly lower in Groups II and III when compared to Group I.There were no difference in the incidence of nausea and vomiting between groups, but an itching sensation was frequent in Group III.The administration of 5 mg of dexamethasone epidurallly, before or after operation, could reduce the pain and analgesic requirement after radical subtotal gastrectomy.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science Gil Medical Center, Incheon, Korea.

ABSTRACT

Background: Epidurally administered dexamethasone may reduce the incidence and severity of postoperative pain. We investigated whether postoperative pain could be alleviated by preoperative or postoperative epidural dexamethasone administration in patients undergoing major abdominal surgery.

Methods: Ninety patients (age 30-77 with American Society of Anesthesiologists physical status I and II) undergoing radical subtotal gastrectomy were randomly allocated to three groups using computer generated randomization. In all groups, 10 ml of 0.25% ropivacaine was injected epidurally before the start and at the end of the operation. In Group I, a bolus ropivacaine epidural without dexamethasone was administered. In Group II, dexamethasone (5 mg) was added to the ropivacaine bolus epidural before the start of operation. In Group III, the same amount of dexamethasone was given with the ropivacaine epidural at the end of operation. Effort and resting VAS, the use of rescue analgesics and any complications noted during the procedure were evaluated.

Results: VAS and requirements of rescue analgesics were significantly lower in Groups II and III when compared to Group I. There were no difference in the incidence of nausea and vomiting between groups, but an itching sensation was frequent in Group III.

Conclusions: The administration of 5 mg of dexamethasone epidurallly, before or after operation, could reduce the pain and analgesic requirement after radical subtotal gastrectomy.

No MeSH data available.


Related in: MedlinePlus

Resting and effort visual analogue scale (VAS). T1: 5 min after arrival in post-anesthetic care unit, T2: discharge time from the post-anesthetic care unit, T3: 24 h after the operation, T4: 48 h after the operation. *P < 0.05 vs. Group I.
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Figure 1: Resting and effort visual analogue scale (VAS). T1: 5 min after arrival in post-anesthetic care unit, T2: discharge time from the post-anesthetic care unit, T3: 24 h after the operation, T4: 48 h after the operation. *P < 0.05 vs. Group I.

Mentions: There were no significant differences in patient characteristics between groups (Table 1). The resting VAS was significantly lower in Group II at T2 compared to Group I. In Group III, the resting VAS was significantly lower at T2, T3, and T4 than in Group I. The effort VAS was significantly lower in Group III than in Group I at T3 and T4 (Fig. 1).


The effect of epidural administration of dexamethasone on postoperative pain: a randomized controlled study in radical subtotal gastrectomy.

Jo YY, Yoo JH, Kim HJ, Kil HK - Korean J Anesthesiol (2011)

Resting and effort visual analogue scale (VAS). T1: 5 min after arrival in post-anesthetic care unit, T2: discharge time from the post-anesthetic care unit, T3: 24 h after the operation, T4: 48 h after the operation. *P < 0.05 vs. Group I.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198185&req=5

Figure 1: Resting and effort visual analogue scale (VAS). T1: 5 min after arrival in post-anesthetic care unit, T2: discharge time from the post-anesthetic care unit, T3: 24 h after the operation, T4: 48 h after the operation. *P < 0.05 vs. Group I.
Mentions: There were no significant differences in patient characteristics between groups (Table 1). The resting VAS was significantly lower in Group II at T2 compared to Group I. In Group III, the resting VAS was significantly lower at T2, T3, and T4 than in Group I. The effort VAS was significantly lower in Group III than in Group I at T3 and T4 (Fig. 1).

Bottom Line: VAS and requirements of rescue analgesics were significantly lower in Groups II and III when compared to Group I.There were no difference in the incidence of nausea and vomiting between groups, but an itching sensation was frequent in Group III.The administration of 5 mg of dexamethasone epidurallly, before or after operation, could reduce the pain and analgesic requirement after radical subtotal gastrectomy.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science Gil Medical Center, Incheon, Korea.

ABSTRACT

Background: Epidurally administered dexamethasone may reduce the incidence and severity of postoperative pain. We investigated whether postoperative pain could be alleviated by preoperative or postoperative epidural dexamethasone administration in patients undergoing major abdominal surgery.

Methods: Ninety patients (age 30-77 with American Society of Anesthesiologists physical status I and II) undergoing radical subtotal gastrectomy were randomly allocated to three groups using computer generated randomization. In all groups, 10 ml of 0.25% ropivacaine was injected epidurally before the start and at the end of the operation. In Group I, a bolus ropivacaine epidural without dexamethasone was administered. In Group II, dexamethasone (5 mg) was added to the ropivacaine bolus epidural before the start of operation. In Group III, the same amount of dexamethasone was given with the ropivacaine epidural at the end of operation. Effort and resting VAS, the use of rescue analgesics and any complications noted during the procedure were evaluated.

Results: VAS and requirements of rescue analgesics were significantly lower in Groups II and III when compared to Group I. There were no difference in the incidence of nausea and vomiting between groups, but an itching sensation was frequent in Group III.

Conclusions: The administration of 5 mg of dexamethasone epidurallly, before or after operation, could reduce the pain and analgesic requirement after radical subtotal gastrectomy.

No MeSH data available.


Related in: MedlinePlus