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Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus

Effect of VPA treatment on sociability and exploratory behavior. (A) Juvenile rats treated with a single dose of VPA spend less time with a novel rat. (B) This effect is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (C) Juvenile rats treated with a single dose of VPA explore more than controls. (D) This is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.
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Figure 4: Effect of VPA treatment on sociability and exploratory behavior. (A) Juvenile rats treated with a single dose of VPA spend less time with a novel rat. (B) This effect is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (C) Juvenile rats treated with a single dose of VPA explore more than controls. (D) This is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.

Mentions: Subjects with disorders involving disturbed sensory processing often exhibit abnormal social interaction (Ayres, 1979). We assessed sociability using an established paradigm (Crawley, 2004) in which we monitored the behavior of a freely moving test rat in a multiple-compartment chamber in which an age and sex-matched “stranger” rat is restricted to one enclosed compartment (see Materials and Methods). Juvenile rats treated with a single dose of VPA (n = 29), but not those treated with multiple doses, spent significantly less time (p = 0.03, Mann–Whitney U) with a novel rat when compared to controls (Figure 4A). Adult rats treated with either a single dose (n = 8) or multiple doses (n = 13) of VPA also did not differ from controls (Figure 4B) in the amount of time they spent with a novel rat.


Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Effect of VPA treatment on sociability and exploratory behavior. (A) Juvenile rats treated with a single dose of VPA spend less time with a novel rat. (B) This effect is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (C) Juvenile rats treated with a single dose of VPA explore more than controls. (D) This is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198155&req=5

Figure 4: Effect of VPA treatment on sociability and exploratory behavior. (A) Juvenile rats treated with a single dose of VPA spend less time with a novel rat. (B) This effect is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (C) Juvenile rats treated with a single dose of VPA explore more than controls. (D) This is reversed in adults. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.
Mentions: Subjects with disorders involving disturbed sensory processing often exhibit abnormal social interaction (Ayres, 1979). We assessed sociability using an established paradigm (Crawley, 2004) in which we monitored the behavior of a freely moving test rat in a multiple-compartment chamber in which an age and sex-matched “stranger” rat is restricted to one enclosed compartment (see Materials and Methods). Juvenile rats treated with a single dose of VPA (n = 29), but not those treated with multiple doses, spent significantly less time (p = 0.03, Mann–Whitney U) with a novel rat when compared to controls (Figure 4A). Adult rats treated with either a single dose (n = 8) or multiple doses (n = 13) of VPA also did not differ from controls (Figure 4B) in the amount of time they spent with a novel rat.

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus