Limits...
Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus

Effect of VPA treatment on nociceptive behavior. (A–D). Stimulus response curves to mechanical stimulation of the vibrissae pad. Juvenile rats treated with a single dose of VPA (A) show increased sensitivity to mechanical stimuli. (B) This effect was reversed in adults. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show increased sensitivity to mechanical stimuli applied to the face. (E–F) Stimulus response curves to mechanical stimulation of the hindpaw. (E) Juvenile rats treated with a single dose of VPA show increased sensitivity to mechanical stimuli. (F) This is reversed in adults. (G,H) Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (I) VPA-treated rats show decreased sensitivity to thermal noxious stimulus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3198155&req=5

Figure 3: Effect of VPA treatment on nociceptive behavior. (A–D). Stimulus response curves to mechanical stimulation of the vibrissae pad. Juvenile rats treated with a single dose of VPA (A) show increased sensitivity to mechanical stimuli. (B) This effect was reversed in adults. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show increased sensitivity to mechanical stimuli applied to the face. (E–F) Stimulus response curves to mechanical stimulation of the hindpaw. (E) Juvenile rats treated with a single dose of VPA show increased sensitivity to mechanical stimuli. (F) This is reversed in adults. (G,H) Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (I) VPA-treated rats show decreased sensitivity to thermal noxious stimulus.

Mentions: When stimuli were applied to the face, juvenile rats treated with a single dose of VPA (n = 56 vibrissae pads) showed a significant decrease in threshold (p = 0.005, Mann–Whitney U, Figure 3A) when compared to controls (n = 26). Juvenile rats treated with multiple doses of VPA (n = 68) also showed lowered thresholds to mechanical stimuli in comparison to control rats (n = 40, p = 0.04, Mann–Whitney U, Figure 3C). When stimuli were applied to the hindpaw, only juvenile rats treated with a single dose of VPA (n = 56) exhibited a significant decrease in threshold (p = 0.0002, Mann–Whitney U, Figure 3E), whereas the multiple dose paradigm of VPA (n = 42) had no significant effect (Figure 3G).


Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Effect of VPA treatment on nociceptive behavior. (A–D). Stimulus response curves to mechanical stimulation of the vibrissae pad. Juvenile rats treated with a single dose of VPA (A) show increased sensitivity to mechanical stimuli. (B) This effect was reversed in adults. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show increased sensitivity to mechanical stimuli applied to the face. (E–F) Stimulus response curves to mechanical stimulation of the hindpaw. (E) Juvenile rats treated with a single dose of VPA show increased sensitivity to mechanical stimuli. (F) This is reversed in adults. (G,H) Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (I) VPA-treated rats show decreased sensitivity to thermal noxious stimulus.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198155&req=5

Figure 3: Effect of VPA treatment on nociceptive behavior. (A–D). Stimulus response curves to mechanical stimulation of the vibrissae pad. Juvenile rats treated with a single dose of VPA (A) show increased sensitivity to mechanical stimuli. (B) This effect was reversed in adults. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show increased sensitivity to mechanical stimuli applied to the face. (E–F) Stimulus response curves to mechanical stimulation of the hindpaw. (E) Juvenile rats treated with a single dose of VPA show increased sensitivity to mechanical stimuli. (F) This is reversed in adults. (G,H) Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls. (I) VPA-treated rats show decreased sensitivity to thermal noxious stimulus.
Mentions: When stimuli were applied to the face, juvenile rats treated with a single dose of VPA (n = 56 vibrissae pads) showed a significant decrease in threshold (p = 0.005, Mann–Whitney U, Figure 3A) when compared to controls (n = 26). Juvenile rats treated with multiple doses of VPA (n = 68) also showed lowered thresholds to mechanical stimuli in comparison to control rats (n = 40, p = 0.04, Mann–Whitney U, Figure 3C). When stimuli were applied to the hindpaw, only juvenile rats treated with a single dose of VPA (n = 56) exhibited a significant decrease in threshold (p = 0.0002, Mann–Whitney U, Figure 3E), whereas the multiple dose paradigm of VPA (n = 42) had no significant effect (Figure 3G).

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus