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Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus

VPA-treated rats exhibit abnormal startle responses and prepulse inhibition. Acoustic startle response of animals receiving a single dose (A,B) or multiple doses of VPA (C,D). (A) Juvenile rats receiving a single dose of VPA show decreased responses to high intensity acoustic stimuli. (B) These changes are reversed in adult rats. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show no difference from controls. (E,F). Juvenile and adult prepulse inhibition. (E) Juvenile rats treated with a single dose of VPA show decreased prepulse inhibition. (F) This is reversed in adult rats. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.
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Figure 2: VPA-treated rats exhibit abnormal startle responses and prepulse inhibition. Acoustic startle response of animals receiving a single dose (A,B) or multiple doses of VPA (C,D). (A) Juvenile rats receiving a single dose of VPA show decreased responses to high intensity acoustic stimuli. (B) These changes are reversed in adult rats. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show no difference from controls. (E,F). Juvenile and adult prepulse inhibition. (E) Juvenile rats treated with a single dose of VPA show decreased prepulse inhibition. (F) This is reversed in adult rats. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.

Mentions: A common finding in subjects with sensory processing disturbances is an abnormal response to auditory stimuli (Ayres, 1979), which can be measured by the startle response. The acoustic startle response quantifies the velocity of movement in response to a sudden sound. The startle response of juvenile rats exposed in utero to a single dose of VPA (n = 29) was significantly different (ps < 0.05, one-way ANOVA, Bonferroni post hoc) than that of age-matched controls for several decibel levels (n = 18; Figure 2A). Rats treated with a multiple injections of VPA responded similarly to controls except for a significantly lowered startle response at 97 dB (Figure 2C). By contrast, in adults there were no significant differences in the startle responses for VPA-treated rats that received either a single injection of VPA (n = 8) or multiple injections of VPA (n = 13; Figures 2B,D) when compared to their respective controls.


Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

VPA-treated rats exhibit abnormal startle responses and prepulse inhibition. Acoustic startle response of animals receiving a single dose (A,B) or multiple doses of VPA (C,D). (A) Juvenile rats receiving a single dose of VPA show decreased responses to high intensity acoustic stimuli. (B) These changes are reversed in adult rats. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show no difference from controls. (E,F). Juvenile and adult prepulse inhibition. (E) Juvenile rats treated with a single dose of VPA show decreased prepulse inhibition. (F) This is reversed in adult rats. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198155&req=5

Figure 2: VPA-treated rats exhibit abnormal startle responses and prepulse inhibition. Acoustic startle response of animals receiving a single dose (A,B) or multiple doses of VPA (C,D). (A) Juvenile rats receiving a single dose of VPA show decreased responses to high intensity acoustic stimuli. (B) These changes are reversed in adult rats. Juvenile (C) and adult (D) rats treated with multiple doses of VPA show no difference from controls. (E,F). Juvenile and adult prepulse inhibition. (E) Juvenile rats treated with a single dose of VPA show decreased prepulse inhibition. (F) This is reversed in adult rats. Juvenile and adult rats treated with multiple doses of VPA respond similarly to controls.
Mentions: A common finding in subjects with sensory processing disturbances is an abnormal response to auditory stimuli (Ayres, 1979), which can be measured by the startle response. The acoustic startle response quantifies the velocity of movement in response to a sudden sound. The startle response of juvenile rats exposed in utero to a single dose of VPA (n = 29) was significantly different (ps < 0.05, one-way ANOVA, Bonferroni post hoc) than that of age-matched controls for several decibel levels (n = 18; Figure 2A). Rats treated with a multiple injections of VPA responded similarly to controls except for a significantly lowered startle response at 97 dB (Figure 2C). By contrast, in adults there were no significant differences in the startle responses for VPA-treated rats that received either a single injection of VPA (n = 8) or multiple injections of VPA (n = 13; Figures 2B,D) when compared to their respective controls.

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus