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Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus

Photomicrographs of Nissl-stained coronal sections through the superior colliculus, depicting the regions used for stereological analyses. We defined the lateral border of the intermediate/deep layers of the superior colliculus by a line extending from the lateral edge of the superficial layers to the lateral border of the periaqueductal gray (PAG). (A–C) Show increasingly more posterior sections and subsequently adjusted borders.
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Figure 1: Photomicrographs of Nissl-stained coronal sections through the superior colliculus, depicting the regions used for stereological analyses. We defined the lateral border of the intermediate/deep layers of the superior colliculus by a line extending from the lateral edge of the superficial layers to the lateral border of the periaqueductal gray (PAG). (A–C) Show increasingly more posterior sections and subsequently adjusted borders.

Mentions: StereoInvestigator’s (MBF Biosciences, Williston, VT, USA) optical fractionator probe was used to obtain unbiased estimates of cell number, cell density, and area volume. Counting frames were 50 μm by 50 μm; grid size was 305 μm by 175 μm; guard zones were 5 μm; and dissector height was 15 μm. Whereas the borders of the superficial layer of the superior colliculus are distinct, the borders of the intermediate and deep layers are not. To circumvent any ambiguity, we defined the lateral border of these regions as a transverse line extending from the lateral edge of the superficial layer to the lateral most border of the periaqueductal gray (PAG; see Figure 1).


Prenatal VPA Exposure and Changes in Sensory Processing by the Superior Colliculus.

Dendrinos G, Hemelt M, Keller A - Front Integr Neurosci (2011)

Photomicrographs of Nissl-stained coronal sections through the superior colliculus, depicting the regions used for stereological analyses. We defined the lateral border of the intermediate/deep layers of the superior colliculus by a line extending from the lateral edge of the superficial layers to the lateral border of the periaqueductal gray (PAG). (A–C) Show increasingly more posterior sections and subsequently adjusted borders.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198155&req=5

Figure 1: Photomicrographs of Nissl-stained coronal sections through the superior colliculus, depicting the regions used for stereological analyses. We defined the lateral border of the intermediate/deep layers of the superior colliculus by a line extending from the lateral edge of the superficial layers to the lateral border of the periaqueductal gray (PAG). (A–C) Show increasingly more posterior sections and subsequently adjusted borders.
Mentions: StereoInvestigator’s (MBF Biosciences, Williston, VT, USA) optical fractionator probe was used to obtain unbiased estimates of cell number, cell density, and area volume. Counting frames were 50 μm by 50 μm; grid size was 305 μm by 175 μm; guard zones were 5 μm; and dissector height was 15 μm. Whereas the borders of the superficial layer of the superior colliculus are distinct, the borders of the intermediate and deep layers are not. To circumvent any ambiguity, we defined the lateral border of these regions as a transverse line extending from the lateral edge of the superficial layer to the lateral most border of the periaqueductal gray (PAG; see Figure 1).

Bottom Line: Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs.Some deficits reversed with age.These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

View Article: PubMed Central - PubMed

Affiliation: Program in Neuroscience, Department of Anatomy and Neurobiology, University of Maryland School of Medicine Baltimore, MD, USA.

ABSTRACT
Disorders involving dysfunctional sensory processing are characterized by an inability to filter sensory information, particularly simultaneously arriving multimodal inputs. We examined the effects of prenatal exposure to valproic acid (VPA), a teratogen linked to sensory dysfunction, on the behavior of juvenile and adult rats, and on the anatomy of the superior colliculus, a critical multisensory integration center in the brain. VPA-exposed rats showed deficits in colliculus-dependent behaviors including startle response, prepulse inhibition, and nociceptive responses. Some deficits reversed with age. Stereological analyses revealed that colliculi of VPA-treated rats had significantly fewer parvalbumin-positive neurons, a subset of GABAergic cells. These results suggest that prenatal VPA treatment affects the development of the superior colliculus and leads to persistent anatomical changes evidenced by aberrant behavior in tasks that require sensory processing.

No MeSH data available.


Related in: MedlinePlus