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Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancy.

Petry CJ, Seear RV, Wingate DL, Manico L, Acerini CL, Ong KK, Hughes IA, Dunger DB - Diabetes (2011)

Bottom Line: Associations were tested between inferred parent-of-origin fetal alleles, z scores of maternal glucose concentrations 60 min. after an oral glucose load performed at week 28 of pregnancy, and offspring birth weights.Using the minimum P value test, paternally transmitted fetal IGF2 polymorphisms were associated with maternal glucose concentrations; specifically, paternally transmitted fetal rs6578987 (P = 0.006), rs680 (P = 0.01), rs10770125 (P = 0.0002), and rs7924316 (P = 0.01) alleles were associated with increased maternal glucose concentrations in the third trimester of pregnancy and placental IGF-II contents at birth (P = 0.03).Polymorphic variation in paternally transmitted fetal IGF2 is associated with increased maternal glucose concentrations in pregnancy and could potentially alter the risk of gestational diabetes in the mother.

View Article: PubMed Central - PubMed

Affiliation: Department of Paediatrics, University of Cambridge, Cambridge, UK. cjp1002@cam.ac.uk

ABSTRACT

Objective: To test the hypothesis that polymorphic variation in the paternally transmitted fetal IGF2 gene is associated with maternal glucose concentrations in the third trimester of pregnancy.

Research design and methods: A total of 17 haplotype tag single nucleotide polymorphisms in the IGF2 gene region were genotyped in 1,160 mother/partner/offspring trios from the prospective Cambridge Baby Growth Study (n = 845 trios) and the retrospective Cambridge Wellbeing Study (n = 315 trios) (3,480 samples in total). Associations were tested between inferred parent-of-origin fetal alleles, z scores of maternal glucose concentrations 60 min. after an oral glucose load performed at week 28 of pregnancy, and offspring birth weights.

Results: Using the minimum P value test, paternally transmitted fetal IGF2 polymorphisms were associated with maternal glucose concentrations; specifically, paternally transmitted fetal rs6578987 (P = 0.006), rs680 (P = 0.01), rs10770125 (P = 0.0002), and rs7924316 (P = 0.01) alleles were associated with increased maternal glucose concentrations in the third trimester of pregnancy and placental IGF-II contents at birth (P = 0.03). In contrast, there were no associations between maternal glucose concentrations and maternal or maternally transmitted fetal IGF2 genotypes.

Conclusions: Polymorphic variation in paternally transmitted fetal IGF2 is associated with increased maternal glucose concentrations in pregnancy and could potentially alter the risk of gestational diabetes in the mother. The association may be at least partially mediated by changes in placental IGF2 expression.

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Error bar graph showing mean (95% CI) maternal glucose concentration z scores 60 min postglucose load according to 1) paternally transmitted and 2) maternally transmitted fetal IGF2 alleles at rs6578987, rs680, rs10770125, and rs7924316.
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Figure 2: Error bar graph showing mean (95% CI) maternal glucose concentration z scores 60 min postglucose load according to 1) paternally transmitted and 2) maternally transmitted fetal IGF2 alleles at rs6578987, rs680, rs10770125, and rs7924316.

Mentions: Haplotype block 1 fetal alleles were associated with maternal glucose z score (P = 0.048) but not with offspring birth weight (P = 0.7). The paternally transmitted fetal rs6578987 C allele was associated with increased maternal glucose z score (P = 0.006; without significant interaction with offspring sex, P = 0.5) (Fig. 2). The maternally transmitted fetal rs6578987 allele and the rs4341514 alleles (irrespective of their parent of origin) were not associated with maternal glucose z scores.


Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancy.

Petry CJ, Seear RV, Wingate DL, Manico L, Acerini CL, Ong KK, Hughes IA, Dunger DB - Diabetes (2011)

Error bar graph showing mean (95% CI) maternal glucose concentration z scores 60 min postglucose load according to 1) paternally transmitted and 2) maternally transmitted fetal IGF2 alleles at rs6578987, rs680, rs10770125, and rs7924316.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198064&req=5

Figure 2: Error bar graph showing mean (95% CI) maternal glucose concentration z scores 60 min postglucose load according to 1) paternally transmitted and 2) maternally transmitted fetal IGF2 alleles at rs6578987, rs680, rs10770125, and rs7924316.
Mentions: Haplotype block 1 fetal alleles were associated with maternal glucose z score (P = 0.048) but not with offspring birth weight (P = 0.7). The paternally transmitted fetal rs6578987 C allele was associated with increased maternal glucose z score (P = 0.006; without significant interaction with offspring sex, P = 0.5) (Fig. 2). The maternally transmitted fetal rs6578987 allele and the rs4341514 alleles (irrespective of their parent of origin) were not associated with maternal glucose z scores.

Bottom Line: Associations were tested between inferred parent-of-origin fetal alleles, z scores of maternal glucose concentrations 60 min. after an oral glucose load performed at week 28 of pregnancy, and offspring birth weights.Using the minimum P value test, paternally transmitted fetal IGF2 polymorphisms were associated with maternal glucose concentrations; specifically, paternally transmitted fetal rs6578987 (P = 0.006), rs680 (P = 0.01), rs10770125 (P = 0.0002), and rs7924316 (P = 0.01) alleles were associated with increased maternal glucose concentrations in the third trimester of pregnancy and placental IGF-II contents at birth (P = 0.03).Polymorphic variation in paternally transmitted fetal IGF2 is associated with increased maternal glucose concentrations in pregnancy and could potentially alter the risk of gestational diabetes in the mother.

View Article: PubMed Central - PubMed

Affiliation: Department of Paediatrics, University of Cambridge, Cambridge, UK. cjp1002@cam.ac.uk

ABSTRACT

Objective: To test the hypothesis that polymorphic variation in the paternally transmitted fetal IGF2 gene is associated with maternal glucose concentrations in the third trimester of pregnancy.

Research design and methods: A total of 17 haplotype tag single nucleotide polymorphisms in the IGF2 gene region were genotyped in 1,160 mother/partner/offspring trios from the prospective Cambridge Baby Growth Study (n = 845 trios) and the retrospective Cambridge Wellbeing Study (n = 315 trios) (3,480 samples in total). Associations were tested between inferred parent-of-origin fetal alleles, z scores of maternal glucose concentrations 60 min. after an oral glucose load performed at week 28 of pregnancy, and offspring birth weights.

Results: Using the minimum P value test, paternally transmitted fetal IGF2 polymorphisms were associated with maternal glucose concentrations; specifically, paternally transmitted fetal rs6578987 (P = 0.006), rs680 (P = 0.01), rs10770125 (P = 0.0002), and rs7924316 (P = 0.01) alleles were associated with increased maternal glucose concentrations in the third trimester of pregnancy and placental IGF-II contents at birth (P = 0.03). In contrast, there were no associations between maternal glucose concentrations and maternal or maternally transmitted fetal IGF2 genotypes.

Conclusions: Polymorphic variation in paternally transmitted fetal IGF2 is associated with increased maternal glucose concentrations in pregnancy and could potentially alter the risk of gestational diabetes in the mother. The association may be at least partially mediated by changes in placental IGF2 expression.

Show MeSH
Related in: MedlinePlus