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Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

Søndergaard E, Nellemann B, Sørensen LP, Gormsen LC, Christiansen JS, Ernst E, Dueholm M, Nielsen S - Diabetes (2011)

Bottom Line: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity.A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat.The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Objective: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.

Research design and methods: Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL.

Results: VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat.

Conclusions: VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.

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Fractional VLDL-TG storage vs. VLDL-TG concentration. A: Visceral fat. B: UBSQ fat. C: LBSQ fat. ● = UBO, ○ = lean, *P < 0.05.
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Figure 3: Fractional VLDL-TG storage vs. VLDL-TG concentration. A: Visceral fat. B: UBSQ fat. C: LBSQ fat. ● = UBO, ○ = lean, *P < 0.05.

Mentions: In lean women, fractional VLDL-TG storage in visceral (r = −0.89, P = 0.02) and LBSQ (r = −0.87, P = 0.02) fat was inversely associated with VLDL-TG concentration (Fig. 3A–C). In UBSQ fat, a similar but not significant relationship was observed (Fig. 3B). In UBO women, a tendency toward a positive relationship was observed between fractional VLDL-TG storage and VLDL-TG concentration in all regional fat depots, although only significant in UBSQ fat (r = 0.68, P = 0.04) (Fig. 3). No significant correlations were observed between fractional VLDL-TG storage and VLDL-TG secretion in any of the regional depots in UBO and lean women.


Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

Søndergaard E, Nellemann B, Sørensen LP, Gormsen LC, Christiansen JS, Ernst E, Dueholm M, Nielsen S - Diabetes (2011)

Fractional VLDL-TG storage vs. VLDL-TG concentration. A: Visceral fat. B: UBSQ fat. C: LBSQ fat. ● = UBO, ○ = lean, *P < 0.05.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198059&req=5

Figure 3: Fractional VLDL-TG storage vs. VLDL-TG concentration. A: Visceral fat. B: UBSQ fat. C: LBSQ fat. ● = UBO, ○ = lean, *P < 0.05.
Mentions: In lean women, fractional VLDL-TG storage in visceral (r = −0.89, P = 0.02) and LBSQ (r = −0.87, P = 0.02) fat was inversely associated with VLDL-TG concentration (Fig. 3A–C). In UBSQ fat, a similar but not significant relationship was observed (Fig. 3B). In UBO women, a tendency toward a positive relationship was observed between fractional VLDL-TG storage and VLDL-TG concentration in all regional fat depots, although only significant in UBSQ fat (r = 0.68, P = 0.04) (Fig. 3). No significant correlations were observed between fractional VLDL-TG storage and VLDL-TG secretion in any of the regional depots in UBO and lean women.

Bottom Line: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity.A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat.The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Objective: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.

Research design and methods: Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL.

Results: VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat.

Conclusions: VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.

Show MeSH
Related in: MedlinePlus