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Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

Søndergaard E, Nellemann B, Sørensen LP, Gormsen LC, Christiansen JS, Ernst E, Dueholm M, Nielsen S - Diabetes (2011)

Bottom Line: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity.A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat.The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Objective: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.

Research design and methods: Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL.

Results: VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat.

Conclusions: VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.

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Related in: MedlinePlus

Study protocol.
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Figure 1: Study protocol.

Mentions: Figure 1 illustrates the study protocol. Participants were admitted to the Elective Surgery Section on the day of the procedure at 0745 h (t = −15 min) after a 10–14 h overnight fast. A catheter was placed in an antecubital vein, and at 0800 h (t = 0 min) a bolus of [9,10-3H]VLDL-TG was infused. At t = 165 min, the participant was taken to the operating room and anesthetized. A biopsy from omental fat was obtained immediately after the tubal occlusion procedure (t = ∼190 min). Immediately after the laparoscopic procedure, biopsies were obtained from UBSQ and LBSQ adipose tissue (t = ∼200 min). After blood sampling at 210 min, the participants were awakened from anesthesia and followed a normal postoperative procedure.


Similar VLDL-TG storage in visceral and subcutaneous fat in obese and lean women.

Søndergaard E, Nellemann B, Sørensen LP, Gormsen LC, Christiansen JS, Ernst E, Dueholm M, Nielsen S - Diabetes (2011)

Study protocol.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3198059&req=5

Figure 1: Study protocol.
Mentions: Figure 1 illustrates the study protocol. Participants were admitted to the Elective Surgery Section on the day of the procedure at 0745 h (t = −15 min) after a 10–14 h overnight fast. A catheter was placed in an antecubital vein, and at 0800 h (t = 0 min) a bolus of [9,10-3H]VLDL-TG was infused. At t = 165 min, the participant was taken to the operating room and anesthetized. A biopsy from omental fat was obtained immediately after the tubal occlusion procedure (t = ∼190 min). Immediately after the laparoscopic procedure, biopsies were obtained from UBSQ and LBSQ adipose tissue (t = ∼200 min). After blood sampling at 210 min, the participants were awakened from anesthesia and followed a normal postoperative procedure.

Bottom Line: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity.A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat.The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots.

View Article: PubMed Central - PubMed

Affiliation: Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

ABSTRACT

Objective: Excess visceral fat accumulation is associated with the metabolic disturbances of obesity. Differential lipid redistribution through lipoproteins may affect body fat distribution. This is the first study to investigate VLDL-triglyceride (VLDL-TG) storage in visceral fat.

Research design and methods: Nine upper-body obese (UBO; waist circumference >88 cm) and six lean (waist circumference <80 cm) women scheduled for elective tubal ligation surgery were studied. VLDL-TG storage in visceral, upper-body subcutaneous (UBSQ), and lower-body subcutaneous (LBSQ) fat were measured with [9,10-(3)H]-triolein-labeled VLDL.

Results: VLDL-TG storage in visceral fat accounted for only ~0.8% of VLDL-TG turnover in UBO and lean women, respectively. A significantly larger proportion of VLDL-TG turnover was stored in UBSQ (~5%) and LBSQ (~4%) fat. The VLDL-TG fractional storage was similar in UBO and lean women for all regional depots. VLDL-TG fractional storage and VLDL-TG concentration were correlated in UBO women in UBSQ fat (r = 0.68, P = 0.04), whereas an inverse association was observed for lean women in visceral (r = -0.89, P = 0.02) and LBSQ (r = -0.87, P = 0.02) fat.

Conclusions: VLDL-TG storage efficiency is similar in all regional fat depots, and trafficking of VLDL-TG into different adipose tissue depots is similar in UBO and lean women. Postabsorptive VLDL-TG storage is unlikely to be of major importance in the development of preferential upper-body fat distribution in obese women.

Show MeSH
Related in: MedlinePlus