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Noroviruses in children seen in a hospital for acute gastroenteritis in Finland.

Räsänen S, Lappalainen S, Salminen M, Huhti L, Vesikari T - Eur. J. Pediatr. (2011)

Bottom Line: NoVs were found in 196 (26%) cases.RVs were found respectively in 128 (38%) and 260 (62%) cases in these two seasons.The median clinical severity of NoV AGE was 14 compared to 16 for RV AGE on a 20-point scale.

View Article: PubMed Central - PubMed

Affiliation: University of Tampere Medical School, FM3, Biokatu 10, 33520 Tampere, Finland. sirpa.rasanen@uta.fi

ABSTRACT

Unlabelled: Noroviruses (NoVs) are second only to rotaviruses (RVs) as causative agents of acute gastroenteritis (AGE) in children. The proportional role of NoVs is likely to increase after control of RV by vaccination. We investigated NoVs in children seen in Tampere University Hospital either treated as outpatients or hospitalized because of AGE before universal RV vaccination was implemented in Finland. This prospective study was conducted from September 2006 to August 2008. A total of 1,128 children <15 years of age with symptoms of AGE were enrolled either in the hospital clinic or in a ward, and stool samples for NoV studies were obtained from 759 children. NoVs were found in 196 (26%) cases. In the first year, NoVs were found in 116 (34%) out of 341, and in the second year, in 80 (19%) out of 418 cases. RVs were found respectively in 128 (38%) and 260 (62%) cases in these two seasons. Both RV and NoV were present in 24 cases. NoV genotype GII.4 predominated with a 96% share of the NoV cases in the first season and an 80% share in the second season. Other NoV genotypes seen infrequently were GII.7, GIIb, GI.6, GII.1, GII.2, and GIIc. The median clinical severity of NoV AGE was 14 compared to 16 for RV AGE on a 20-point scale.

Conclusion: NoVs were nearly as common as RVs as causative agents of severe AGE in children seen in hospital. After implementing universal RV vaccination, the importance of NoVs will still increase further.

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Related in: MedlinePlus

Seasonality of the noroviruses seen in acute gastroenteritis in children (September 2006–August 2008) in Tampere University Hospital
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Fig2: Seasonality of the noroviruses seen in acute gastroenteritis in children (September 2006–August 2008) in Tampere University Hospital

Mentions: A clear seasonality was seen in NoV AGE in both years. The most active NoV period in the first season was from February to April 2007 and in the second season from January to April 2008 (Fig. 2). The SaV AGE cases were scattered with no obvious seasonality.Fig. 2


Noroviruses in children seen in a hospital for acute gastroenteritis in Finland.

Räsänen S, Lappalainen S, Salminen M, Huhti L, Vesikari T - Eur. J. Pediatr. (2011)

Seasonality of the noroviruses seen in acute gastroenteritis in children (September 2006–August 2008) in Tampere University Hospital
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3197931&req=5

Fig2: Seasonality of the noroviruses seen in acute gastroenteritis in children (September 2006–August 2008) in Tampere University Hospital
Mentions: A clear seasonality was seen in NoV AGE in both years. The most active NoV period in the first season was from February to April 2007 and in the second season from January to April 2008 (Fig. 2). The SaV AGE cases were scattered with no obvious seasonality.Fig. 2

Bottom Line: NoVs were found in 196 (26%) cases.RVs were found respectively in 128 (38%) and 260 (62%) cases in these two seasons.The median clinical severity of NoV AGE was 14 compared to 16 for RV AGE on a 20-point scale.

View Article: PubMed Central - PubMed

Affiliation: University of Tampere Medical School, FM3, Biokatu 10, 33520 Tampere, Finland. sirpa.rasanen@uta.fi

ABSTRACT

Unlabelled: Noroviruses (NoVs) are second only to rotaviruses (RVs) as causative agents of acute gastroenteritis (AGE) in children. The proportional role of NoVs is likely to increase after control of RV by vaccination. We investigated NoVs in children seen in Tampere University Hospital either treated as outpatients or hospitalized because of AGE before universal RV vaccination was implemented in Finland. This prospective study was conducted from September 2006 to August 2008. A total of 1,128 children <15 years of age with symptoms of AGE were enrolled either in the hospital clinic or in a ward, and stool samples for NoV studies were obtained from 759 children. NoVs were found in 196 (26%) cases. In the first year, NoVs were found in 116 (34%) out of 341, and in the second year, in 80 (19%) out of 418 cases. RVs were found respectively in 128 (38%) and 260 (62%) cases in these two seasons. Both RV and NoV were present in 24 cases. NoV genotype GII.4 predominated with a 96% share of the NoV cases in the first season and an 80% share in the second season. Other NoV genotypes seen infrequently were GII.7, GIIb, GI.6, GII.1, GII.2, and GIIc. The median clinical severity of NoV AGE was 14 compared to 16 for RV AGE on a 20-point scale.

Conclusion: NoVs were nearly as common as RVs as causative agents of severe AGE in children seen in hospital. After implementing universal RV vaccination, the importance of NoVs will still increase further.

Show MeSH
Related in: MedlinePlus