Hippocampal pyramidal cells: the reemergence of cortical lamination.
Bottom Line: Distributions of deep and superficial pyramidal cell dendrites and studies in reeler or sparsely GFP-expressing mice indicate that this also applies to afferent pathways.Histological, neurochemical, and connective differences between deep and superficial neurons may correlate with (patho-) physiological phenomena specific to pyramidal cells at different radial locations.We feel that an appreciation of radial subdivisions in the pyramidal cell layer reminiscent of lamination in other cortical areas may be critical in the interpretation of studies of hippocampal anatomy and function.
Affiliation: Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland. firstname.lastname@example.orgShow MeSH
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Mentions: Based on this short review we feel that it is very difficult to maintain the concept of pyramidal cell homogeneity along the radial axis of the cell layer. Rather it seems that in many species distinct deep and superficial populations of pyramidal cells can be identified, which differ in neurochemistry, connectivity, and their reactions to selective pressures exerted during the phylogeny of particular species. Examples of features distinguishing superficial and deep CA1 pyramidal cells are summarized in Fig. 6. A similar division of CA3 pyramidal cells may be superimposed on stronger proximo-distal gradients.Fig. 6
Affiliation: Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland. email@example.com