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Hippocampal pyramidal cells: the reemergence of cortical lamination.

Slomianka L, Amrein I, Knuesel I, Sørensen JC, Wolfer DP - Brain Struct Funct (2011)

Bottom Line: Distributions of deep and superficial pyramidal cell dendrites and studies in reeler or sparsely GFP-expressing mice indicate that this also applies to afferent pathways.Histological, neurochemical, and connective differences between deep and superficial neurons may correlate with (patho-) physiological phenomena specific to pyramidal cells at different radial locations.We feel that an appreciation of radial subdivisions in the pyramidal cell layer reminiscent of lamination in other cortical areas may be critical in the interpretation of studies of hippocampal anatomy and function.

View Article: PubMed Central - PubMed

Affiliation: Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland. slomianka@anatom.uzh.ch

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Examples of particularly interesting histoarchitectural, connectional, neurochemical and pathological findings that distinguish superficial and deep pyramidal cells of CA1. The cell layer has been drawn to resemble the different appearances of the layer along both the septotemporal and proximodistal axis in mouse and rat. In other species much of CA1 is dominated by a histoarchitectural phenotype that encompasses only a narrow segment of the variations seen in rat and mouse
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Fig6: Examples of particularly interesting histoarchitectural, connectional, neurochemical and pathological findings that distinguish superficial and deep pyramidal cells of CA1. The cell layer has been drawn to resemble the different appearances of the layer along both the septotemporal and proximodistal axis in mouse and rat. In other species much of CA1 is dominated by a histoarchitectural phenotype that encompasses only a narrow segment of the variations seen in rat and mouse

Mentions: Based on this short review we feel that it is very difficult to maintain the concept of pyramidal cell homogeneity along the radial axis of the cell layer. Rather it seems that in many species distinct deep and superficial populations of pyramidal cells can be identified, which differ in neurochemistry, connectivity, and their reactions to selective pressures exerted during the phylogeny of particular species. Examples of features distinguishing superficial and deep CA1 pyramidal cells are summarized in Fig. 6. A similar division of CA3 pyramidal cells may be superimposed on stronger proximo-distal gradients.Fig. 6


Hippocampal pyramidal cells: the reemergence of cortical lamination.

Slomianka L, Amrein I, Knuesel I, Sørensen JC, Wolfer DP - Brain Struct Funct (2011)

Examples of particularly interesting histoarchitectural, connectional, neurochemical and pathological findings that distinguish superficial and deep pyramidal cells of CA1. The cell layer has been drawn to resemble the different appearances of the layer along both the septotemporal and proximodistal axis in mouse and rat. In other species much of CA1 is dominated by a histoarchitectural phenotype that encompasses only a narrow segment of the variations seen in rat and mouse
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3197924&req=5

Fig6: Examples of particularly interesting histoarchitectural, connectional, neurochemical and pathological findings that distinguish superficial and deep pyramidal cells of CA1. The cell layer has been drawn to resemble the different appearances of the layer along both the septotemporal and proximodistal axis in mouse and rat. In other species much of CA1 is dominated by a histoarchitectural phenotype that encompasses only a narrow segment of the variations seen in rat and mouse
Mentions: Based on this short review we feel that it is very difficult to maintain the concept of pyramidal cell homogeneity along the radial axis of the cell layer. Rather it seems that in many species distinct deep and superficial populations of pyramidal cells can be identified, which differ in neurochemistry, connectivity, and their reactions to selective pressures exerted during the phylogeny of particular species. Examples of features distinguishing superficial and deep CA1 pyramidal cells are summarized in Fig. 6. A similar division of CA3 pyramidal cells may be superimposed on stronger proximo-distal gradients.Fig. 6

Bottom Line: Distributions of deep and superficial pyramidal cell dendrites and studies in reeler or sparsely GFP-expressing mice indicate that this also applies to afferent pathways.Histological, neurochemical, and connective differences between deep and superficial neurons may correlate with (patho-) physiological phenomena specific to pyramidal cells at different radial locations.We feel that an appreciation of radial subdivisions in the pyramidal cell layer reminiscent of lamination in other cortical areas may be critical in the interpretation of studies of hippocampal anatomy and function.

View Article: PubMed Central - PubMed

Affiliation: Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland. slomianka@anatom.uzh.ch

Show MeSH
Related in: MedlinePlus