Hippocampal pyramidal cells: the reemergence of cortical lamination.
Bottom Line: Distributions of deep and superficial pyramidal cell dendrites and studies in reeler or sparsely GFP-expressing mice indicate that this also applies to afferent pathways.Histological, neurochemical, and connective differences between deep and superficial neurons may correlate with (patho-) physiological phenomena specific to pyramidal cells at different radial locations.We feel that an appreciation of radial subdivisions in the pyramidal cell layer reminiscent of lamination in other cortical areas may be critical in the interpretation of studies of hippocampal anatomy and function.
Affiliation: Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland. email@example.comShow MeSH
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Mentions: Morphological differences between cells at different radial locations in the pyramidal cell layer and the maintenance of spatial relations according to neuronal birthdays may still be accommodated within the idea that the pyramidal cells are a radially homogeneous population of neurons. However, a migration defect in reeler mice does not result in a simple “inside-out” to “outside-in” reversal. Neither does this mutation result in the random scattering of cells that is observed for the dentate granule cells. Instead pyramidal cells are sorted, according to their time of generation, into two, more or less distinct, sublayers (Fig. 3a–e; Caviness 1973; Stanfield and Cowan 1979a, b; Deller et al. 1999; Coulin et al. 2001). Early born cells concentrate in a layer close to the alveus. This layer is separated by a cell-sparse zone from a layer formed by lately born cells closer to the obliterated hippocampal fissure.Fig. 3
Affiliation: Institute of Anatomy, University of Zürich, 8057 Zürich, Switzerland. firstname.lastname@example.org