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Effect of Oral Administration of Acetaminophen and Topical Application of EMLA on Pain during Transrectal Ultrasound-Guided Prostate Biopsy.

Kim S, Yoon BI, Kim SJ, Cho HJ, Kim HS, Hong SH, Lee JY, Hwang TK, Kim SW - Korean J Urol (2011)

Bottom Line: We compared with pain-relieving effect of acetaminophen, a known drug for enhancing the pain-relieving effect of tramadol, and eutectic mixture of local anesthetics (EMLA), a local anesthetic agent, with that of the conventional periprostatic nerve block method.The pain scores for groups 2 and group 3, which were 3.47±1.92 and 3.50±1.36, respectively, were similar and were significantly lower than that of group 1, which was 5.24±2.07.These methods were more effective for pain relief than was the conventional periprostatic nerve block method.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Purpose: Transrectal ultrasound-guided prostate biopsy is the procedure of choice for diagnosing prostate cancer. We compared with pain-relieving effect of acetaminophen, a known drug for enhancing the pain-relieving effect of tramadol, and eutectic mixture of local anesthetics (EMLA), a local anesthetic agent, with that of the conventional periprostatic nerve block method.

Materials and methods: This was a prospective, randomized, single-blinded study. A total of 430 patients were randomly assigned to three groups. Group 1 received a periprostatic nerve block with 1% lidocaine, group 2 received acetaminophen 650 mg, and group 3 received EMLA cream for pain control. All patients were given 50 mg of tramadol intravenously 30 minutes before the procedure. At 3 hours after completion of the procedure, the patients were asked to grade their pain on a horizontal visual analogue scale (VAS). The patients were also asked whether they were willing to undergo future biopsy if required.

Results: There were no significant differences between the three groups in terms of age, prostate-specific antigen, prostate size, or numbers of biopsy cores. The pain scores for groups 2 and group 3, which were 3.47±1.92 and 3.50±1.36, respectively, were similar and were significantly lower than that of group 1, which was 5.24±2.07.

Conclusions: Acetaminophen and EMLA cream with intravenous injection of tramadol are safe, easy, and effective methods of controlling pain during the procedure. These methods were more effective for pain relief than was the conventional periprostatic nerve block method.

No MeSH data available.


Related in: MedlinePlus

Pain scale (0-10 visual analogue pain scale).
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Related In: Results  -  Collection

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Figure 1: Pain scale (0-10 visual analogue pain scale).

Mentions: Three hours after prostate biopsy, by a single-blind method, a third person evaluated the pain that was felt during the insertion of the transrectal ultrasound probe by using a visual analogue scale (VAS) (Fig. 1). A score of 0 was defined as no pain, and 10 points was defined as the most severe intolerable pain. In addition, we surveyed whether the patients were willing to undergo another prostate biopsy in the future if required. After 3 days, the pain that developed during the biopsy and the presence of complications were assessed again in telephone interviews.


Effect of Oral Administration of Acetaminophen and Topical Application of EMLA on Pain during Transrectal Ultrasound-Guided Prostate Biopsy.

Kim S, Yoon BI, Kim SJ, Cho HJ, Kim HS, Hong SH, Lee JY, Hwang TK, Kim SW - Korean J Urol (2011)

Pain scale (0-10 visual analogue pain scale).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3151631&req=5

Figure 1: Pain scale (0-10 visual analogue pain scale).
Mentions: Three hours after prostate biopsy, by a single-blind method, a third person evaluated the pain that was felt during the insertion of the transrectal ultrasound probe by using a visual analogue scale (VAS) (Fig. 1). A score of 0 was defined as no pain, and 10 points was defined as the most severe intolerable pain. In addition, we surveyed whether the patients were willing to undergo another prostate biopsy in the future if required. After 3 days, the pain that developed during the biopsy and the presence of complications were assessed again in telephone interviews.

Bottom Line: We compared with pain-relieving effect of acetaminophen, a known drug for enhancing the pain-relieving effect of tramadol, and eutectic mixture of local anesthetics (EMLA), a local anesthetic agent, with that of the conventional periprostatic nerve block method.The pain scores for groups 2 and group 3, which were 3.47±1.92 and 3.50±1.36, respectively, were similar and were significantly lower than that of group 1, which was 5.24±2.07.These methods were more effective for pain relief than was the conventional periprostatic nerve block method.

View Article: PubMed Central - PubMed

Affiliation: Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

ABSTRACT

Purpose: Transrectal ultrasound-guided prostate biopsy is the procedure of choice for diagnosing prostate cancer. We compared with pain-relieving effect of acetaminophen, a known drug for enhancing the pain-relieving effect of tramadol, and eutectic mixture of local anesthetics (EMLA), a local anesthetic agent, with that of the conventional periprostatic nerve block method.

Materials and methods: This was a prospective, randomized, single-blinded study. A total of 430 patients were randomly assigned to three groups. Group 1 received a periprostatic nerve block with 1% lidocaine, group 2 received acetaminophen 650 mg, and group 3 received EMLA cream for pain control. All patients were given 50 mg of tramadol intravenously 30 minutes before the procedure. At 3 hours after completion of the procedure, the patients were asked to grade their pain on a horizontal visual analogue scale (VAS). The patients were also asked whether they were willing to undergo future biopsy if required.

Results: There were no significant differences between the three groups in terms of age, prostate-specific antigen, prostate size, or numbers of biopsy cores. The pain scores for groups 2 and group 3, which were 3.47±1.92 and 3.50±1.36, respectively, were similar and were significantly lower than that of group 1, which was 5.24±2.07.

Conclusions: Acetaminophen and EMLA cream with intravenous injection of tramadol are safe, easy, and effective methods of controlling pain during the procedure. These methods were more effective for pain relief than was the conventional periprostatic nerve block method.

No MeSH data available.


Related in: MedlinePlus