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Evaluation of Transforming Growth Factor Beta-1 Gene 869T/C Polymorphism with Hypertension: A Meta-Analysis.

Niu W - Int J Hypertens (2011)

Bottom Line: Data were available from 9 study populations involving 6151 subjects.Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies with OR, except in the dominant model, being increased by 7.94-18.61%.Likewise, ethnicity-based analysis exhibited a contradictory association between Asians and Whites.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology, and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Second Road 197, Shanghai 200025, China.

ABSTRACT
Association between transforming growth factor beta-1 gene (TGFB1) 869T/C polymorphism and hypertension has been widely evaluated, yet with conflicting results. As meta-analysis is a reliable way to resolve discrepancies; I aimed to evaluate this association. Data were available from 9 study populations involving 6151 subjects. Overall, comparison of allele 869C with 869T generated a significant 30% increased hypertension risk (95% confidence interval [95% CI]: 1.11-1.51; P = 0.001), which was strengthened for homozygous comparison (869CC versus 869TT) with odds ratio (OR) doubled to 1.62 (95% CI: 1.23-2.14; P = 0.001). Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies with OR, except in the dominant model, being increased by 7.94-18.61%. Likewise, ethnicity-based analysis exhibited a contradictory association between Asians and Whites. Conclusively, these findings support the notion that TGFB1 gene 869T/C polymorphism may influence the risk of hypertension, especially in Asian populations.

No MeSH data available.


Related in: MedlinePlus

Stratified analysis of TGFB1 gene 869T/C polymorphism by ethnicity with hypertension in the allelic (a), homozygous (b), dominant (c), and recessive (d) models.
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fig4: Stratified analysis of TGFB1 gene 869T/C polymorphism by ethnicity with hypertension in the allelic (a), homozygous (b), dominant (c), and recessive (d) models.

Mentions: Further ethnicity-stratified analysis indicated strikingly heterogeneous associations of 869T/C polymorphism with hypertension, by showing a contradictory association between Asians and Whites (Figure 4). In Asians, I consistently observed a risk-conferring effect of the 869C allele or 869CC genotype for hypertension, even upon stratification by countries, as well as Chinese ethnic groups. Contrastingly, after restricting analysis to Whites, although there was just one study [12], I hereto observed a protective effect (OR = 0.84–0.92), and the corresponding wide confidence intervals in all genetic models gave an indication of insufficient study power in White populations.


Evaluation of Transforming Growth Factor Beta-1 Gene 869T/C Polymorphism with Hypertension: A Meta-Analysis.

Niu W - Int J Hypertens (2011)

Stratified analysis of TGFB1 gene 869T/C polymorphism by ethnicity with hypertension in the allelic (a), homozygous (b), dominant (c), and recessive (d) models.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3142626&req=5

fig4: Stratified analysis of TGFB1 gene 869T/C polymorphism by ethnicity with hypertension in the allelic (a), homozygous (b), dominant (c), and recessive (d) models.
Mentions: Further ethnicity-stratified analysis indicated strikingly heterogeneous associations of 869T/C polymorphism with hypertension, by showing a contradictory association between Asians and Whites (Figure 4). In Asians, I consistently observed a risk-conferring effect of the 869C allele or 869CC genotype for hypertension, even upon stratification by countries, as well as Chinese ethnic groups. Contrastingly, after restricting analysis to Whites, although there was just one study [12], I hereto observed a protective effect (OR = 0.84–0.92), and the corresponding wide confidence intervals in all genetic models gave an indication of insufficient study power in White populations.

Bottom Line: Data were available from 9 study populations involving 6151 subjects.Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies with OR, except in the dominant model, being increased by 7.94-18.61%.Likewise, ethnicity-based analysis exhibited a contradictory association between Asians and Whites.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Vascular Biology, and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Second Road 197, Shanghai 200025, China.

ABSTRACT
Association between transforming growth factor beta-1 gene (TGFB1) 869T/C polymorphism and hypertension has been widely evaluated, yet with conflicting results. As meta-analysis is a reliable way to resolve discrepancies; I aimed to evaluate this association. Data were available from 9 study populations involving 6151 subjects. Overall, comparison of allele 869C with 869T generated a significant 30% increased hypertension risk (95% confidence interval [95% CI]: 1.11-1.51; P = 0.001), which was strengthened for homozygous comparison (869CC versus 869TT) with odds ratio (OR) doubled to 1.62 (95% CI: 1.23-2.14; P = 0.001). Stratified analysis by study design demonstrated stronger associations in population-based studies than in hospital-based studies with OR, except in the dominant model, being increased by 7.94-18.61%. Likewise, ethnicity-based analysis exhibited a contradictory association between Asians and Whites. Conclusively, these findings support the notion that TGFB1 gene 869T/C polymorphism may influence the risk of hypertension, especially in Asian populations.

No MeSH data available.


Related in: MedlinePlus