Possible involvement of caveolin in attenuation of cardioprotective effect of ischemic preconditioning in diabetic rat heart.
Bottom Line: IPC- induced cardioprotection and release of NO was significantly decreased in diabetic rat heart.Pre-treatment of diabetic rat with daidzein (DDZ) a caveolin inhibitor (0.2 mg/Kg/s.c), for one week, significantly increased the release of NO and restored the attenuated cardioprotective effect of IPC.Also perfusion of sodium nitrite (10 μM/L), a precursor of NO, significantly restored the lost effect of IPC, similar to daidzein in diabetic rat.
Affiliation: Department of Pharmacology, Indo-Soviet College of Pharmacy, Moga 142-001, Punjab, India.Show MeSH
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Mentions: Four episodes of IPC significantly increased the release of nitrite into coronary effluent of normal animals, as compared to I/R group but not in isolated heart obtained from diabetic rat. Treatment with daidzein, a caveolin inhibitor (0.2 mg/Kg/s.c, one week), significantly increased, the release of nitrite in diabetic rat heart subjected to IPC (Figure 6).
Affiliation: Department of Pharmacology, Indo-Soviet College of Pharmacy, Moga 142-001, Punjab, India.