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Possible involvement of caveolin in attenuation of cardioprotective effect of ischemic preconditioning in diabetic rat heart.

Ajmani P, Yadav HN, Singh M, Sharma PL - BMC Cardiovasc Disord (2011)

Bottom Line: IPC- induced cardioprotection and release of NO was significantly decreased in diabetic rat heart.Pre-treatment of diabetic rat with daidzein (DDZ) a caveolin inhibitor (0.2 mg/Kg/s.c), for one week, significantly increased the release of NO and restored the attenuated cardioprotective effect of IPC.Also perfusion of sodium nitrite (10 μM/L), a precursor of NO, significantly restored the lost effect of IPC, similar to daidzein in diabetic rat.

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Affiliation: Department of Pharmacology, Indo-Soviet College of Pharmacy, Moga 142-001, Punjab, India.

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Effect of ischemic preconditioning (IPC) and treatment of DDZ, on the release of nitric oxice in diabetic rat heart. I/R, IPC, DM, DDZ, denotes ischemia reperfusion, ischemic preconditioning, diabetes mellitus and daidzein respectively. Values are expressed as mean ± S.D, a = p < 0.05 vs. I/R Control; b = p < 0.05 vs .IPC in diabetic rat heart.
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Figure 6: Effect of ischemic preconditioning (IPC) and treatment of DDZ, on the release of nitric oxice in diabetic rat heart. I/R, IPC, DM, DDZ, denotes ischemia reperfusion, ischemic preconditioning, diabetes mellitus and daidzein respectively. Values are expressed as mean ± S.D, a = p < 0.05 vs. I/R Control; b = p < 0.05 vs .IPC in diabetic rat heart.

Mentions: Four episodes of IPC significantly increased the release of nitrite into coronary effluent of normal animals, as compared to I/R group but not in isolated heart obtained from diabetic rat. Treatment with daidzein, a caveolin inhibitor (0.2 mg/Kg/s.c, one week), significantly increased, the release of nitrite in diabetic rat heart subjected to IPC (Figure 6).


Possible involvement of caveolin in attenuation of cardioprotective effect of ischemic preconditioning in diabetic rat heart.

Ajmani P, Yadav HN, Singh M, Sharma PL - BMC Cardiovasc Disord (2011)

Effect of ischemic preconditioning (IPC) and treatment of DDZ, on the release of nitric oxice in diabetic rat heart. I/R, IPC, DM, DDZ, denotes ischemia reperfusion, ischemic preconditioning, diabetes mellitus and daidzein respectively. Values are expressed as mean ± S.D, a = p < 0.05 vs. I/R Control; b = p < 0.05 vs .IPC in diabetic rat heart.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3142229&req=5

Figure 6: Effect of ischemic preconditioning (IPC) and treatment of DDZ, on the release of nitric oxice in diabetic rat heart. I/R, IPC, DM, DDZ, denotes ischemia reperfusion, ischemic preconditioning, diabetes mellitus and daidzein respectively. Values are expressed as mean ± S.D, a = p < 0.05 vs. I/R Control; b = p < 0.05 vs .IPC in diabetic rat heart.
Mentions: Four episodes of IPC significantly increased the release of nitrite into coronary effluent of normal animals, as compared to I/R group but not in isolated heart obtained from diabetic rat. Treatment with daidzein, a caveolin inhibitor (0.2 mg/Kg/s.c, one week), significantly increased, the release of nitrite in diabetic rat heart subjected to IPC (Figure 6).

Bottom Line: IPC- induced cardioprotection and release of NO was significantly decreased in diabetic rat heart.Pre-treatment of diabetic rat with daidzein (DDZ) a caveolin inhibitor (0.2 mg/Kg/s.c), for one week, significantly increased the release of NO and restored the attenuated cardioprotective effect of IPC.Also perfusion of sodium nitrite (10 μM/L), a precursor of NO, significantly restored the lost effect of IPC, similar to daidzein in diabetic rat.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pharmacology, Indo-Soviet College of Pharmacy, Moga 142-001, Punjab, India.

Show MeSH
Related in: MedlinePlus