Limits...
Application of supercritical antisolvent method in drug encapsulation: a review.

Kalani M, Yunus R - Int J Nanomedicine (2011)

Bottom Line: The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation.The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated.The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO(2) flow rate, and the liquid phase flow rate on particle size and its distribution.

View Article: PubMed Central - PubMed

Affiliation: Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, Malaysia. mahshid.kalani@gmail.com

ABSTRACT
The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO(2) flow rate, and the liquid phase flow rate on particle size and its distribution.

Show MeSH

Related in: MedlinePlus

Density dependence of CO2 at various temperatures.17Note: Reproduced from Gupta and Kompella with permission from the publisher.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3141870&req=5

f3-ijn-6-1429: Density dependence of CO2 at various temperatures.17Note: Reproduced from Gupta and Kompella with permission from the publisher.

Mentions: The density of supercritical fluid affects mass transfer between organic solvent and supercritical fluid during precipitation. The density of supercritical fluid depends on the temperature and pressure parameters of the fluid, as shown in Figure 3.


Application of supercritical antisolvent method in drug encapsulation: a review.

Kalani M, Yunus R - Int J Nanomedicine (2011)

Density dependence of CO2 at various temperatures.17Note: Reproduced from Gupta and Kompella with permission from the publisher.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3141870&req=5

f3-ijn-6-1429: Density dependence of CO2 at various temperatures.17Note: Reproduced from Gupta and Kompella with permission from the publisher.
Mentions: The density of supercritical fluid affects mass transfer between organic solvent and supercritical fluid during precipitation. The density of supercritical fluid depends on the temperature and pressure parameters of the fluid, as shown in Figure 3.

Bottom Line: The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation.The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated.The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO(2) flow rate, and the liquid phase flow rate on particle size and its distribution.

View Article: PubMed Central - PubMed

Affiliation: Chemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, Malaysia. mahshid.kalani@gmail.com

ABSTRACT
The review focuses on the application of supercritical fluids as antisolvents in the pharmaceutical field and demonstrates the supercritical antisolvent method in the use of drug encapsulation. The main factors for choosing the solvent and biodegradable polymer to produce fine particles to ensure effective drug delivery are emphasized and the effect of polymer structure on drug encapsulation is illustrated. The review also demonstrates the drug release mechanism and polymeric controlled release system, and discusses the effects of the various conditions in the process, such as pressure, temperature, concentration, chemical compositions (organic solvents, drug, and biodegradable polymer), nozzle geometry, CO(2) flow rate, and the liquid phase flow rate on particle size and its distribution.

Show MeSH
Related in: MedlinePlus