Limits...
Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent.

Hussein MZ, Al Ali SH, Zainal Z, Hakim MN - Int J Nanomedicine (2011)

Bottom Line: The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability.The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation.In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Selangor, Malaysia. mzobir@science.upm.my

ABSTRACT
An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

Show MeSH
Fitting of the data of EA released from the EAN into solution to the zeroth-, first-, pseudo-second-order kinetics, and parabolic diffusion for 0.1 M Na2CO3 (A, B, C, and D respectively) and Na3PO4 (E, F, G, and H, respectively).Abbreviations: EA, ellagic acid; EAN, ellagic acid nanohybrid; ZnO, zinc oxide.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3141866&req=5

f9-ijn-6-1373: Fitting of the data of EA released from the EAN into solution to the zeroth-, first-, pseudo-second-order kinetics, and parabolic diffusion for 0.1 M Na2CO3 (A, B, C, and D respectively) and Na3PO4 (E, F, G, and H, respectively).Abbreviations: EA, ellagic acid; EAN, ellagic acid nanohybrid; ZnO, zinc oxide.

Mentions: In order to obtain more information on the release behavior of EA from EAN, zeroth-, first-, pseudo-second-order kinetics and parabolic diffusion, were chosen to investigate the release kinetics of EA from the nanohybrid. The equations are given in Table 2. On the basis of the four models, the fitted results of EA release profiles are given in Figure 9 and Table 2. It can be seen that the pseudo-second-order model can be better fitted to the data of the EA release behavior than the other models. Figures 9C and G show the plots of t/qt versus t for the release of EA into Na2CO3 and Na3PO4 solution, respectively. For the Na2CO3, the correlation coefficient (R2) and k valves are 0.9985 and 0.0044, respectively, compared with 0.9996 and 0.0175, respectively for Na3PO4. The saturated release amount, correlation coefficient (R2) and rate constant for pseudo-second-order model are also given in Table 2. This study indicates that EAN synthesized in this work shows controlled-release properties.


Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent.

Hussein MZ, Al Ali SH, Zainal Z, Hakim MN - Int J Nanomedicine (2011)

Fitting of the data of EA released from the EAN into solution to the zeroth-, first-, pseudo-second-order kinetics, and parabolic diffusion for 0.1 M Na2CO3 (A, B, C, and D respectively) and Na3PO4 (E, F, G, and H, respectively).Abbreviations: EA, ellagic acid; EAN, ellagic acid nanohybrid; ZnO, zinc oxide.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3141866&req=5

f9-ijn-6-1373: Fitting of the data of EA released from the EAN into solution to the zeroth-, first-, pseudo-second-order kinetics, and parabolic diffusion for 0.1 M Na2CO3 (A, B, C, and D respectively) and Na3PO4 (E, F, G, and H, respectively).Abbreviations: EA, ellagic acid; EAN, ellagic acid nanohybrid; ZnO, zinc oxide.
Mentions: In order to obtain more information on the release behavior of EA from EAN, zeroth-, first-, pseudo-second-order kinetics and parabolic diffusion, were chosen to investigate the release kinetics of EA from the nanohybrid. The equations are given in Table 2. On the basis of the four models, the fitted results of EA release profiles are given in Figure 9 and Table 2. It can be seen that the pseudo-second-order model can be better fitted to the data of the EA release behavior than the other models. Figures 9C and G show the plots of t/qt versus t for the release of EA into Na2CO3 and Na3PO4 solution, respectively. For the Na2CO3, the correlation coefficient (R2) and k valves are 0.9985 and 0.0044, respectively, compared with 0.9996 and 0.0175, respectively for Na3PO4. The saturated release amount, correlation coefficient (R2) and rate constant for pseudo-second-order model are also given in Table 2. This study indicates that EAN synthesized in this work shows controlled-release properties.

Bottom Line: The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability.The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation.In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Selangor, Malaysia. mzobir@science.upm.my

ABSTRACT
An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

Show MeSH