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Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent.

Hussein MZ, Al Ali SH, Zainal Z, Hakim MN - Int J Nanomedicine (2011)

Bottom Line: The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability.The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation.In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Selangor, Malaysia. mzobir@science.upm.my

ABSTRACT
An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

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FTIR spectrum of EA (A) and EAN (B).Abbreviations: FTIR, Fourier transform infra-red; EA, ellagic acid; EAN, ellagic acid nanohybrid.
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f3-ijn-6-1373: FTIR spectrum of EA (A) and EAN (B).Abbreviations: FTIR, Fourier transform infra-red; EA, ellagic acid; EAN, ellagic acid nanohybrid.

Mentions: The FTIR spectra of the EAN nanohybrid and EA are given in Figure 3. The FTIR spectrum of EA shows an absorption band at 3557 cm−1, attributed to the stretching mode of OH groups in the phenol at 7,7′, 8 and 8′ positions (Figure 2A)52 and broad absorption bands at 3500–2750 cm−1 can be attributed to stretching of C–H aromatic ring24 and hydrogen bond between EA molecules.50 A band at 1700 cm−1 is due to stretching of C=O52,53 and bands at 1620–1511 cm−1 are due to aromatic rings. A band at 1196 and 1058 cm−1 is due to ester linkage of C–O stretching34,52 and another band at 758 cm−1 is due to C–H aromatic stretching.


Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent.

Hussein MZ, Al Ali SH, Zainal Z, Hakim MN - Int J Nanomedicine (2011)

FTIR spectrum of EA (A) and EAN (B).Abbreviations: FTIR, Fourier transform infra-red; EA, ellagic acid; EAN, ellagic acid nanohybrid.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3141866&req=5

f3-ijn-6-1373: FTIR spectrum of EA (A) and EAN (B).Abbreviations: FTIR, Fourier transform infra-red; EA, ellagic acid; EAN, ellagic acid nanohybrid.
Mentions: The FTIR spectra of the EAN nanohybrid and EA are given in Figure 3. The FTIR spectrum of EA shows an absorption band at 3557 cm−1, attributed to the stretching mode of OH groups in the phenol at 7,7′, 8 and 8′ positions (Figure 2A)52 and broad absorption bands at 3500–2750 cm−1 can be attributed to stretching of C–H aromatic ring24 and hydrogen bond between EA molecules.50 A band at 1700 cm−1 is due to stretching of C=O52,53 and bands at 1620–1511 cm−1 are due to aromatic rings. A band at 1196 and 1058 cm−1 is due to ester linkage of C–O stretching34,52 and another band at 758 cm−1 is due to C–H aromatic stretching.

Bottom Line: The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability.The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation.In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Selangor, Malaysia. mzobir@science.upm.my

ABSTRACT
An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

Show MeSH