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Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent.

Hussein MZ, Al Ali SH, Zainal Z, Hakim MN - Int J Nanomedicine (2011)

Bottom Line: The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability.The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation.In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Selangor, Malaysia. mzobir@science.upm.my

ABSTRACT
An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

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PXRD patterns of ZnO (A), EAN (B) and EA (C).Abbreviations: PXRD, powder X-ray diffraction; EA, ellagic acid; EAN, ellagic acid nanohybrid.
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f1-ijn-6-1373: PXRD patterns of ZnO (A), EAN (B) and EA (C).Abbreviations: PXRD, powder X-ray diffraction; EA, ellagic acid; EAN, ellagic acid nanohybrid.

Mentions: Figures 1A, B, and C show PXRD patterns of ZnO, EAN, and EA, respectively. For ZnO sample, the five intense reflections shown in Figure 1A at 30–60° correspond to diffractions due to 100, 002, 101, 102, and 110 planes. Figure 1B shows the PXRD pattern of EAN synthesized by direct reaction between 0.025 M hydrated EA with ZnO. As reported in the literature, the zinc hydroxide nitrate has sharp reflection at 9.7 Å due to the 200 plane of the monoclinic structure.47,48 After the intercalation of the anions, the basal distance increased more than 9.7 Å due to the displacement of exchangeable nitrate anions and depending on the dimensions and the spatial orientation of the guest anion that is intercalated into the ZLH inorganic interlayers.48 As shown in the Figure 1B, the formation of the EAN can be confirmed by the observation of two new diffraction patterns at d = 10.4 Å and 5.2 Å, which is due to 003 and 006 reflection, respectively. Total disappearance of the intense peaks of ZnO phase indicated that the sample EAN is pure phase and the ZnO was completely converted to ZLH.36


Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent.

Hussein MZ, Al Ali SH, Zainal Z, Hakim MN - Int J Nanomedicine (2011)

PXRD patterns of ZnO (A), EAN (B) and EA (C).Abbreviations: PXRD, powder X-ray diffraction; EA, ellagic acid; EAN, ellagic acid nanohybrid.
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Related In: Results  -  Collection

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f1-ijn-6-1373: PXRD patterns of ZnO (A), EAN (B) and EA (C).Abbreviations: PXRD, powder X-ray diffraction; EA, ellagic acid; EAN, ellagic acid nanohybrid.
Mentions: Figures 1A, B, and C show PXRD patterns of ZnO, EAN, and EA, respectively. For ZnO sample, the five intense reflections shown in Figure 1A at 30–60° correspond to diffractions due to 100, 002, 101, 102, and 110 planes. Figure 1B shows the PXRD pattern of EAN synthesized by direct reaction between 0.025 M hydrated EA with ZnO. As reported in the literature, the zinc hydroxide nitrate has sharp reflection at 9.7 Å due to the 200 plane of the monoclinic structure.47,48 After the intercalation of the anions, the basal distance increased more than 9.7 Å due to the displacement of exchangeable nitrate anions and depending on the dimensions and the spatial orientation of the guest anion that is intercalated into the ZLH inorganic interlayers.48 As shown in the Figure 1B, the formation of the EAN can be confirmed by the observation of two new diffraction patterns at d = 10.4 Å and 5.2 Å, which is due to 003 and 006 reflection, respectively. Total disappearance of the intense peaks of ZnO phase indicated that the sample EAN is pure phase and the ZnO was completely converted to ZLH.36

Bottom Line: The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability.The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation.In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

View Article: PubMed Central - PubMed

Affiliation: Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology, Selangor, Malaysia. mzobir@science.upm.my

ABSTRACT
An ellagic acid (EA)-zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8' position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host-guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA.

Show MeSH