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Ganglion cell complex and retinal nerve fiber layer measured by fourier-domain optical coherence tomography for early detection of structural damage in patients with preperimetric glaucoma.

Rolle T, Briamonte C, Curto D, Grignolo FM - Clin Ophthalmol (2011)

Bottom Line: Macular and papillary diagnostic accuracies did not differ significantly based on the 95% confidence interval.The computation of the Boolean OR operator has been found to boost diagnostic accuracy.FD-OCT does not seem to be decisive for early detection of structural damage in patients with no functional impairment.

View Article: PubMed Central - PubMed

Affiliation: Eye Clinic, Section of Ophthalmology, Department of Clinical Physiopathology, University of Torino, Torino, Italy. teresa.rolle@unito.it

ABSTRACT

Aims: To evaluate the capability of Fourier-domain optical coherence tomography (FD-OCT) to detect structural damage in patients with preperimetric glaucoma.

Methods: A total of 178 Caucasian subjects were enrolled in this cohort study: 116 preperimetric glaucoma patients and 52 healthy subjects. Using three-dimensional FD-OCT, the participants underwent imaging of the ganglion cell complex (GCC) and the optic nerve head. Sensitivity, specificity, likelihood ratios, and predictive values were calculated for all parameters at the first and fifth percentiles. Areas under the curves (AUCs) were generated for all parameters and were compared (Delong test). For both the GCC and the optic nerve head protocols, the OR logical disjunction (Boolean logic operator) was calculated.

Results: The AUCs didn't significantly differ. Macular global loss volume had the largest AUC (0.81). Specificities were high at both the fifth and first percentiles (up to 97%), but sensitivities were low, especially at the first percentile (55%-27%).

Conclusion: Macular and papillary diagnostic accuracies did not differ significantly based on the 95% confidence interval. The computation of the Boolean OR operator has been found to boost diagnostic accuracy. Using the software-provided classification, sensitivity and diagnostic accuracy were low for both the retinal nerve fiber layer and the GCC scans. FD-OCT does not seem to be decisive for early detection of structural damage in patients with no functional impairment. This suggests that there is a need for analysis software to be further refined to enhance glaucoma diagnostic capability.

No MeSH data available.


Related in: MedlinePlus

Comparison between AUCs.  Abbreviations: AUC, area under the curve; avg, average thickness; FLV, focal loss volume; GCC, ganglion cell complex; GLV, global loss volume; inf, inferior thickness; OR, the OR Boolean operator; RNFL, retinal nerve fiber layer; SE, standard error; sup, superior thickness.
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f7-opth-5-961: Comparison between AUCs. Abbreviations: AUC, area under the curve; avg, average thickness; FLV, focal loss volume; GCC, ganglion cell complex; GLV, global loss volume; inf, inferior thickness; OR, the OR Boolean operator; RNFL, retinal nerve fiber layer; SE, standard error; sup, superior thickness.

Mentions: Based on AUC values obtained in our study, the top three FD-OCT parameters were GCC OR, RNFL OR, and GCC GLV. We could not find a statistically significant difference between the GCC and ONH diagnostic parameters (see Figure 7).


Ganglion cell complex and retinal nerve fiber layer measured by fourier-domain optical coherence tomography for early detection of structural damage in patients with preperimetric glaucoma.

Rolle T, Briamonte C, Curto D, Grignolo FM - Clin Ophthalmol (2011)

Comparison between AUCs.  Abbreviations: AUC, area under the curve; avg, average thickness; FLV, focal loss volume; GCC, ganglion cell complex; GLV, global loss volume; inf, inferior thickness; OR, the OR Boolean operator; RNFL, retinal nerve fiber layer; SE, standard error; sup, superior thickness.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC3141860&req=5

f7-opth-5-961: Comparison between AUCs. Abbreviations: AUC, area under the curve; avg, average thickness; FLV, focal loss volume; GCC, ganglion cell complex; GLV, global loss volume; inf, inferior thickness; OR, the OR Boolean operator; RNFL, retinal nerve fiber layer; SE, standard error; sup, superior thickness.
Mentions: Based on AUC values obtained in our study, the top three FD-OCT parameters were GCC OR, RNFL OR, and GCC GLV. We could not find a statistically significant difference between the GCC and ONH diagnostic parameters (see Figure 7).

Bottom Line: Macular and papillary diagnostic accuracies did not differ significantly based on the 95% confidence interval.The computation of the Boolean OR operator has been found to boost diagnostic accuracy.FD-OCT does not seem to be decisive for early detection of structural damage in patients with no functional impairment.

View Article: PubMed Central - PubMed

Affiliation: Eye Clinic, Section of Ophthalmology, Department of Clinical Physiopathology, University of Torino, Torino, Italy. teresa.rolle@unito.it

ABSTRACT

Aims: To evaluate the capability of Fourier-domain optical coherence tomography (FD-OCT) to detect structural damage in patients with preperimetric glaucoma.

Methods: A total of 178 Caucasian subjects were enrolled in this cohort study: 116 preperimetric glaucoma patients and 52 healthy subjects. Using three-dimensional FD-OCT, the participants underwent imaging of the ganglion cell complex (GCC) and the optic nerve head. Sensitivity, specificity, likelihood ratios, and predictive values were calculated for all parameters at the first and fifth percentiles. Areas under the curves (AUCs) were generated for all parameters and were compared (Delong test). For both the GCC and the optic nerve head protocols, the OR logical disjunction (Boolean logic operator) was calculated.

Results: The AUCs didn't significantly differ. Macular global loss volume had the largest AUC (0.81). Specificities were high at both the fifth and first percentiles (up to 97%), but sensitivities were low, especially at the first percentile (55%-27%).

Conclusion: Macular and papillary diagnostic accuracies did not differ significantly based on the 95% confidence interval. The computation of the Boolean OR operator has been found to boost diagnostic accuracy. Using the software-provided classification, sensitivity and diagnostic accuracy were low for both the retinal nerve fiber layer and the GCC scans. FD-OCT does not seem to be decisive for early detection of structural damage in patients with no functional impairment. This suggests that there is a need for analysis software to be further refined to enhance glaucoma diagnostic capability.

No MeSH data available.


Related in: MedlinePlus