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The comparison of grey-scale ultrasonic and clinical features of hepatoblastoma and hepatocellular carcinoma in children: a retrospective study for ten years.

Zhuang H, Peng YL, Chen TW, Jiang Y, Luo Y, Zhang Q, Yang ZG - BMC Gastroenterol (2011)

Bottom Line: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001).The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02).Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiology, West China Hospital of Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children.

Methods: Thirty cases of the confirmed HBL and 12 cases of the confirmed HCC in children under the age of 15 years were enrolled into our study. They were divided into the HBL group and the HCC group according to the histological types of the tumors. The ultrasonic features and the clinical manifestations of the two groups were retrospectively analyzed, with an emphasis on the following parameters: onset age, gender (male/female) ratio, positive epatitis-B-surface-antigen (HBV), alpha-fetoprotein increase, and echo features including septa, calcification and liquefaction within the tumors.

Results: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001). The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02). When a combination of the liquefaction, septa, negative HBV and onset age smaller than 5 years was used in the evaluation, the sensitivity was raised to 90%, the accuracy was raised to 88%, and the negative predictive value was raised to 73%.

Conclusion: Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

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Related in: MedlinePlus

HBL in the right lobe of the liver in a 4-year-old boy. The liquefaction (arrow) was observed in the center of the tumor and some blood signals were also observed.
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Figure 4: HBL in the right lobe of the liver in a 4-year-old boy. The liquefaction (arrow) was observed in the center of the tumor and some blood signals were also observed.

Mentions: The ultrasonic features of HCC and of HBL were listed in Table 2. There was no significant difference in the location or the number of the tumor between the two groups (P > 0.05). The echo within the tumor mass was significantly different in the septa and the liquefaction between the two diseases (P < 0.001, P = 0.02 respectively). That is to say, septa and liquefaction were easier to be found in HBL than in HCC (Figure 2, 3, 4, 5). But the calcification was occasionally found in both the two kinds of tumors. The lesion size was significantly different between the two groups (P < 0.001). The long-axe diameters of HBL and HCC were 8.5 ± 3.5 cm and 3.7 ± 1.8 cm, respectively. There was no significant difference in the bile duct, the vessel involvement or the blood flow condition (P > 0.05). The portal vein thrombosis and the hepatic vein thrombosis were observed in a few cases of HCC. The background liver cirrhosis was observed only in the children with HCC (Figure 6).


The comparison of grey-scale ultrasonic and clinical features of hepatoblastoma and hepatocellular carcinoma in children: a retrospective study for ten years.

Zhuang H, Peng YL, Chen TW, Jiang Y, Luo Y, Zhang Q, Yang ZG - BMC Gastroenterol (2011)

HBL in the right lobe of the liver in a 4-year-old boy. The liquefaction (arrow) was observed in the center of the tumor and some blood signals were also observed.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3141754&req=5

Figure 4: HBL in the right lobe of the liver in a 4-year-old boy. The liquefaction (arrow) was observed in the center of the tumor and some blood signals were also observed.
Mentions: The ultrasonic features of HCC and of HBL were listed in Table 2. There was no significant difference in the location or the number of the tumor between the two groups (P > 0.05). The echo within the tumor mass was significantly different in the septa and the liquefaction between the two diseases (P < 0.001, P = 0.02 respectively). That is to say, septa and liquefaction were easier to be found in HBL than in HCC (Figure 2, 3, 4, 5). But the calcification was occasionally found in both the two kinds of tumors. The lesion size was significantly different between the two groups (P < 0.001). The long-axe diameters of HBL and HCC were 8.5 ± 3.5 cm and 3.7 ± 1.8 cm, respectively. There was no significant difference in the bile duct, the vessel involvement or the blood flow condition (P > 0.05). The portal vein thrombosis and the hepatic vein thrombosis were observed in a few cases of HCC. The background liver cirrhosis was observed only in the children with HCC (Figure 6).

Bottom Line: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001).The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02).Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiology, West China Hospital of Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children.

Methods: Thirty cases of the confirmed HBL and 12 cases of the confirmed HCC in children under the age of 15 years were enrolled into our study. They were divided into the HBL group and the HCC group according to the histological types of the tumors. The ultrasonic features and the clinical manifestations of the two groups were retrospectively analyzed, with an emphasis on the following parameters: onset age, gender (male/female) ratio, positive epatitis-B-surface-antigen (HBV), alpha-fetoprotein increase, and echo features including septa, calcification and liquefaction within the tumors.

Results: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001). The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02). When a combination of the liquefaction, septa, negative HBV and onset age smaller than 5 years was used in the evaluation, the sensitivity was raised to 90%, the accuracy was raised to 88%, and the negative predictive value was raised to 73%.

Conclusion: Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

Show MeSH
Related in: MedlinePlus