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The comparison of grey-scale ultrasonic and clinical features of hepatoblastoma and hepatocellular carcinoma in children: a retrospective study for ten years.

Zhuang H, Peng YL, Chen TW, Jiang Y, Luo Y, Zhang Q, Yang ZG - BMC Gastroenterol (2011)

Bottom Line: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001).The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02).Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiology, West China Hospital of Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children.

Methods: Thirty cases of the confirmed HBL and 12 cases of the confirmed HCC in children under the age of 15 years were enrolled into our study. They were divided into the HBL group and the HCC group according to the histological types of the tumors. The ultrasonic features and the clinical manifestations of the two groups were retrospectively analyzed, with an emphasis on the following parameters: onset age, gender (male/female) ratio, positive epatitis-B-surface-antigen (HBV), alpha-fetoprotein increase, and echo features including septa, calcification and liquefaction within the tumors.

Results: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001). The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02). When a combination of the liquefaction, septa, negative HBV and onset age smaller than 5 years was used in the evaluation, the sensitivity was raised to 90%, the accuracy was raised to 88%, and the negative predictive value was raised to 73%.

Conclusion: Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

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Related in: MedlinePlus

Histogram shows the different distributions of hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) related to the onset age.
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Figure 1: Histogram shows the different distributions of hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) related to the onset age.

Mentions: The clinical manifestations of the patients were compared between the HCC and HBL groups (Table 1). There was no significant difference in the gender ratio (male/female), jaundice, palpable abdominal lump, AFP increase or abdominal pain (P > 0.05). Both the onset age and the positive HBS-Ag were significantly different between the two groups (P < 0.001). In the histogram for the onset age of the patients in the HBL group and the HCC group, a different distribution could be observed (Figure 1). The onset age was younger than 5 years in 21 patients of the HBL group, whereas older than 10 years in 6 children of the HCC group. That is to say, the average tumor onset-age was younger and the negative HBS-Ag appeared more frequently in the children with HBL than in the children with HCC.


The comparison of grey-scale ultrasonic and clinical features of hepatoblastoma and hepatocellular carcinoma in children: a retrospective study for ten years.

Zhuang H, Peng YL, Chen TW, Jiang Y, Luo Y, Zhang Q, Yang ZG - BMC Gastroenterol (2011)

Histogram shows the different distributions of hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) related to the onset age.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3141754&req=5

Figure 1: Histogram shows the different distributions of hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) related to the onset age.
Mentions: The clinical manifestations of the patients were compared between the HCC and HBL groups (Table 1). There was no significant difference in the gender ratio (male/female), jaundice, palpable abdominal lump, AFP increase or abdominal pain (P > 0.05). Both the onset age and the positive HBS-Ag were significantly different between the two groups (P < 0.001). In the histogram for the onset age of the patients in the HBL group and the HCC group, a different distribution could be observed (Figure 1). The onset age was younger than 5 years in 21 patients of the HBL group, whereas older than 10 years in 6 children of the HCC group. That is to say, the average tumor onset-age was younger and the negative HBS-Ag appeared more frequently in the children with HBL than in the children with HCC.

Bottom Line: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001).The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02).Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Radiology, West China Hospital of Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan 610041, China.

ABSTRACT

Background: Hepatoblastoma (HBL) and hepatocellular carcinoma (HCC) are respectively the first and the second most common pediatric malignant liver tumors. The purpose of this study was to evaluate the combined use of the ultrasound examination and the assessment of the patients' clinical features for differentiating HBL from HCC in children.

Methods: Thirty cases of the confirmed HBL and 12 cases of the confirmed HCC in children under the age of 15 years were enrolled into our study. They were divided into the HBL group and the HCC group according to the histological types of the tumors. The ultrasonic features and the clinical manifestations of the two groups were retrospectively analyzed, with an emphasis on the following parameters: onset age, gender (male/female) ratio, positive epatitis-B-surface-antigen (HBV), alpha-fetoprotein increase, and echo features including septa, calcification and liquefaction within the tumors.

Results: Compared with the children with HCC, the children with HBL had a significantly younger onset age (8.2 years vs. 3.9 years, P < 0.001) and a significantly smaller frequency of positive HBV (66.7% vs. 13.3%, P < 0.001). The septa and liquefaction were more frequently found in HBL than in HCC (25/30, 83.3% vs. 2/12, 16.7%, P < 0.001; 17/30, 56.7% vs. 3/12, 25%, P = 0.02). When a combination of the liquefaction, septa, negative HBV and onset age smaller than 5 years was used in the evaluation, the sensitivity was raised to 90%, the accuracy was raised to 88%, and the negative predictive value was raised to 73%.

Conclusion: Ultrasonic features combined with clinical manifestations are valuable for differentiating HBL from HCC in children.

Show MeSH
Related in: MedlinePlus