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A rare tumour of the breast: carcinosarcoma.

Ilhan E, Vardar E, Ozkok G, Sezgin A, Sahin S, Teker K, Postaci H, Yildirim M - J Clin Med Res (2010)

Bottom Line: Ki67 proliferation index was found 40% positive.There was no metastasis in axillary lymph node and distant metastasis.The patient is receiving chemotherapy and is under follow-up in the 54th month.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

ABSTRACT

Unlabelled: Carcinosarcoma of the breast, also known as metaplastic carcinoma, is rare with very few cases reported in the literature. A 46-year old female patient presented with a mass in her left breast. Physical examination, ultrasonography and mammography findings were consistent with malignancy. The mass was totally removed. Histopathological examination revealed carcinosarcoma of the breast. Histologic grade of the tumour was III. Ki67 proliferation index was found 40% positive. Tumour cells were positive for p53 (70% positive), c-erb-B2 (5% positive), pancytokeratin and EMA in carcinomatous areas, and vimentin in sarcomatous areas. There was no metastasis in axillary lymph node and distant metastasis. The patient is receiving chemotherapy and is under follow-up in the 54th month. Along with a review of the literature, we present the information regarding the clinical and histological findings and treatment of the patient who was operated due to breast carcinosarcoma.

Keywords: Breast; Carcinoma; Carcinosarcoma.

No MeSH data available.


Related in: MedlinePlus

Vesicular chromatin structure and several mitotic figures were seen in tumor cells (HE x 400).
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Figure 3: Vesicular chromatin structure and several mitotic figures were seen in tumor cells (HE x 400).

Mentions: A 46-year old perymenopausal woman (married, having 2 children) presented with a mass present in her right breast which has grown rapidly in 2 months. Physical examination showed a firm mass of 3 cm in greatest dimension with irregular boundaries in the upper inner quadrant of the right breast and no enlarged lymph nodes in the axillary region. Ultrasonography revealed a solid hypoechoic mass of 2.5 cm in greatest dimension displaying irregular boundaries. A radiopaque lesion with irregular boundaries was monitored in mammography. The mass was totally excised under local anesthesia. In gross description the mass measured 2.6 × 2.5 × 2.5 cm and revealed disorganization presenting areas with epithelial and mesenchymal characteristics on histopathological examination. Extensive necrosis was also observed. No lymphovascular thrombi was detected. Epithelial areas with a ductal nature were determined to be of histologic grade III with a total score of 9 (according to the Nottingham modification of Bloom-Richardson grading) consisting of 3 for tubule formation, 3 for nuclear pleomorphism, and 3 for mitotic rate. Ki67 proliferation index was 40% positive. Tumor cells were positive for p53 (70% positive), c-erb-B2 (5% positive),pan-cytokeratin and EMA in carcinomatous areas, and vimentin in sarcomatous areas. All tumor cells were negative for estrogen, progesterone, desmin and SMA (Fig. 1, 2, 3, 4). No metastasis was found in systemic radiological investigations. Right modified radical mastectomy was performed. No residual tumor was found in the excision area in the mastectomy specimen. Histopathological examination of the 26 lymph nodes dissected from the axillary material was consistent with 'reactive hyperplasia'. Having received 6 courses chemotherapy, the case is now in her 54th month and under follow-up with no disease.


A rare tumour of the breast: carcinosarcoma.

Ilhan E, Vardar E, Ozkok G, Sezgin A, Sahin S, Teker K, Postaci H, Yildirim M - J Clin Med Res (2010)

Vesicular chromatin structure and several mitotic figures were seen in tumor cells (HE x 400).
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3140887&req=5

Figure 3: Vesicular chromatin structure and several mitotic figures were seen in tumor cells (HE x 400).
Mentions: A 46-year old perymenopausal woman (married, having 2 children) presented with a mass present in her right breast which has grown rapidly in 2 months. Physical examination showed a firm mass of 3 cm in greatest dimension with irregular boundaries in the upper inner quadrant of the right breast and no enlarged lymph nodes in the axillary region. Ultrasonography revealed a solid hypoechoic mass of 2.5 cm in greatest dimension displaying irregular boundaries. A radiopaque lesion with irregular boundaries was monitored in mammography. The mass was totally excised under local anesthesia. In gross description the mass measured 2.6 × 2.5 × 2.5 cm and revealed disorganization presenting areas with epithelial and mesenchymal characteristics on histopathological examination. Extensive necrosis was also observed. No lymphovascular thrombi was detected. Epithelial areas with a ductal nature were determined to be of histologic grade III with a total score of 9 (according to the Nottingham modification of Bloom-Richardson grading) consisting of 3 for tubule formation, 3 for nuclear pleomorphism, and 3 for mitotic rate. Ki67 proliferation index was 40% positive. Tumor cells were positive for p53 (70% positive), c-erb-B2 (5% positive),pan-cytokeratin and EMA in carcinomatous areas, and vimentin in sarcomatous areas. All tumor cells were negative for estrogen, progesterone, desmin and SMA (Fig. 1, 2, 3, 4). No metastasis was found in systemic radiological investigations. Right modified radical mastectomy was performed. No residual tumor was found in the excision area in the mastectomy specimen. Histopathological examination of the 26 lymph nodes dissected from the axillary material was consistent with 'reactive hyperplasia'. Having received 6 courses chemotherapy, the case is now in her 54th month and under follow-up with no disease.

Bottom Line: Ki67 proliferation index was found 40% positive.There was no metastasis in axillary lymph node and distant metastasis.The patient is receiving chemotherapy and is under follow-up in the 54th month.

View Article: PubMed Central - PubMed

Affiliation: Department of General Surgery, Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

ABSTRACT

Unlabelled: Carcinosarcoma of the breast, also known as metaplastic carcinoma, is rare with very few cases reported in the literature. A 46-year old female patient presented with a mass in her left breast. Physical examination, ultrasonography and mammography findings were consistent with malignancy. The mass was totally removed. Histopathological examination revealed carcinosarcoma of the breast. Histologic grade of the tumour was III. Ki67 proliferation index was found 40% positive. Tumour cells were positive for p53 (70% positive), c-erb-B2 (5% positive), pancytokeratin and EMA in carcinomatous areas, and vimentin in sarcomatous areas. There was no metastasis in axillary lymph node and distant metastasis. The patient is receiving chemotherapy and is under follow-up in the 54th month. Along with a review of the literature, we present the information regarding the clinical and histological findings and treatment of the patient who was operated due to breast carcinosarcoma.

Keywords: Breast; Carcinoma; Carcinosarcoma.

No MeSH data available.


Related in: MedlinePlus